Evidence map›Paper›PMID 37622997›Full record

SynthesisCurrent oncology (Toronto, Ont.)2023

Nanoparticle-Based Treatment Approaches for Skin Cancer: A Systematic Review.

Michael Joseph Diaz, Nicole Natarelli, Shaliz Aflatooni, Sarah J Aleman, Sphurti Neelam, Jasmine Thuy Tran, Kamil Taneja, Brandon Lucke-Wold, Mahtab Forouzandeh

Abstract readSystematic Review
In one paragraph

Synthesis in Current oncology (Toronto, Ont.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Hydroxypropyl Cellulose Hydrogel ContainingGels (Basel, Switzerland) · 2024
    Article
  6. Review
  7. Arsenic Nanoparticles Trigger Apoptosis viaInternational journal of molecular sciences · 2024
    Article
  8. Review
  9. Cutaneous Oncology: Strategies for Melanoma Prevention, Diagnosis, and Therapy.Cancer control : journal of the Moffitt Cancer Center
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Michael Joseph DiazCollege of Medicine, University of Florida, Gainesville, FL 32610, USA.
Nicole NatarelliMorsani College of Medicine, University of South Florida, Tampa, FL 33602, USA.ORCID 0000-0003-0338-5607
Shaliz AflatooniMorsani College of Medicine, University of South Florida, Tampa, FL 33602, USA.
Sarah J AlemanSchool of Medicine, Louisiana State University, New Orleans, LA 70112, USA.
Sphurti NeelamCollege of Medicine, University of Florida, Gainesville, FL 32610, USA.
Jasmine Thuy TranSchool of Medicine, Indiana University, Indianapolis, IN 46202, USA.
Kamil TanejaRenaissance School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA.
Brandon Lucke-WoldDepartment of Neurosurgery, University of Florida, Gainesville, FL 32608, USA.ORCID 0000-0001-6577-4080
Mahtab ForouzandehDepartment of Dermatology, University of Florida, Gainesville, FL 32606, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nanoparticles have shown marked promise as both antineoplastic agents and drug carriers. Despite strides made in immunomodulation, low success rates and toxicity remain limitations within the clinical oncology setting. In the present review, we assess advances in drug delivery nanoparticles, for systemic and topical use, in skin cancer treatment. A systematic review of controlled trials, meta-analyses, and Cochrane review articles was conducted. Eligibility criteria included: (1) a primary focus on nanoparticle utility for skin cancer; (2) available metrics on prevention and treatment outcomes; (3) detailed subject population; (4) English language; (5) archived as full-text journal articles. A total of 43 articles were selected for review. Qualitative analysis revealed that nanoscale systems demonstrate significant antineoplastic and anti-metastasis properties: increased drug bioavailability, reduced toxicity, enhanced permeability and retention effect, as well as tumor growth inhibition, among others. Nanoformulations for skin cancers have largely lagged behind those tested in other cancers-several of which have commercialized formulae. However, emerging evidence has indicated a powerful role for these carriers in targeting primary and metastatic skin cancers.

Indexed as

NanoparticlesSkin NeoplasmsHumansdrug carriersinorganicnanoparticleorganicskin cancersystematic review

Identifiers

PMID37622997
PMCPMC10453819

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.