Evidence map›Paper›PMID 37623972›Full record

ArticlePathogens (Basel, Switzerland)2023

Antiprotozoal Activity of Benzoylthiourea Derivatives against

Patrícia Morais Lopes Pereira, Bruna Terci Fernandes, Vitória Ribeiro Dos Santos, Weslei Roberto Correia Cabral, Maria Isabel Lovo-Martins, Lais Alonso, César Armando Contreras Lancheros, Jéssica Carreira de Paula, Priscila Goes Camargo, Helena Tiemi Suzukawa and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pathogens (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Patrícia Morais Lopes PereiraGraduate Program in Microbiology, Department of Microbiology, State University of Londrina, Londrina 86057-970, Brazil.
Bruna Terci FernandesGraduate Program in Microbiology, Department of Microbiology, State University of Londrina, Londrina 86057-970, Brazil.
Vitória Ribeiro Dos SantosLaboratory of Molecular Biology of Microorganisms, Department of Microbiology, State University of Londrina, Londrina 86057-970, Brazil.
Weslei Roberto Correia CabralGraduate Program in Microbiology, Department of Microbiology, State University of Londrina, Londrina 86057-970, Brazil.
Maria Isabel Lovo-MartinsLaboratory of Experimental Immunopathology, Department of Immunology, Parasitology and General Pathology, State University of Londrina, Londrina 86057-970, Brazil.
Lais AlonsoInstitute of Physics, Federal University of Goiás, Goiania 74690-900, Brazil.
César Armando Contreras LancherosCenter for Human, Biological, Social and Educational Sciences, State University of Paraná, Paranagua 83203-560, Brazil.
Jéssica Carreira de PaulaDepartment of Parasitology, University of Granada, 18071 Granada, Spain.ORCID 0000-0002-6209-9523
Priscila Goes CamargoLaboratory of Medicinal Molecules Synthesis, Department of Chemistry, State University of Londrina, Londrina 86057-970, Brazil.ORCID 0000-0003-4483-2119
Helena Tiemi SuzukawaGraduate Program in Microbiology, Department of Microbiology, State University of Londrina, Londrina 86057-970, Brazil.
Antônio AlonsoInstitute of Physics, Federal University of Goiás, Goiania 74690-900, Brazil.
Fernando MacedoLaboratory of Medicinal Molecules Synthesis, Department of Chemistry, State University of Londrina, Londrina 86057-970, Brazil.
Celso Vataru NakamuraLaboratory of Technological Innovation in the Development of Drugs and Cosmetics, Department of Basic Health Sciences, State University of Maringá, Maringa 87020-900, Brazil.ORCID 0000-0002-9911-7369
Eliandro Reis TavaresLaboratory of Molecular Biology of Microorganisms, Department of Microbiology, State University of Londrina, Londrina 86057-970, Brazil.
Marcelle de Lima Ferreira BispoLaboratory of Medicinal Molecules Synthesis, Department of Chemistry, State University of Londrina, Londrina 86057-970, Brazil.ORCID 0000-0002-6001-360X
Lucy Megumi YamauchiGraduate Program in Microbiology, Department of Microbiology, State University of Londrina, Londrina 86057-970, Brazil.ORCID 0000-0003-2241-8814
Phileno Pinge-FilhoGraduate Program in Microbiology, Department of Microbiology, State University of Londrina, Londrina 86057-970, Brazil.
Sueli Fumie Yamada-OgattaGraduate Program in Microbiology, Department of Microbiology, State University of Londrina, Londrina 86057-970, Brazil.ORCID 0000-0003-1183-146X

Funding

Coordenação de Aperfeicoamento de Pessoal de Nível Superior Financial Code 01
6 · The paper itself

Abstract

For decades, only two nitroheterocyclic drugs have been used as therapeutic agents for Chagas disease. However, these drugs present limited effectiveness during the chronic phase, possess unfavorable pharmacokinetic properties, and induce severe adverse effects, resulting in low treatment adherence. A previous study reported that

Indexed as

autophagy-dependent pathwaycell deathChagas diseaseepimastigote formsmechanism of actionultrastructural changes

Identifiers

PMID37623972
PMCPMC10457850

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.