Evidence map›Paper›PMID 37624150›Full record

ArticleToxics2023

Arsenic Impairs Differentiation of Human Induced Pluripotent Stem Cells into Cholinergic Motor Neurons.

M Chiara Perego, Benjamin D McMichael, Nicholas R McMurry, Scott W Ventrello, Lisa J Bain

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

M Chiara PeregoDepartment of Biological Sciences, Clemson University, Clemson, SC 29634, USA.
Benjamin D McMichaelDepartment of Biology, University of North Carolina, Chapel Hill, NC 27599, USA.ORCID 0000-0002-9270-1570
Nicholas R McMurryDepartment of Biological Sciences, Clemson University, Clemson, SC 29634, USA.
Scott W VentrelloDepartment of Biological Sciences, Clemson University, Clemson, SC 29634, USA.
Lisa J BainDepartment of Biological Sciences, Clemson University, Clemson, SC 29634, USA.
Clemson University · USUniversity of North Carolina at Chapel Hill · US

Funding

Regulation of Cryptosporidium DevelopmentP20GM146584 · NIGMS · CLEMSON UNIVERSITY · PI KERRY Scot SMITH · 2022 to 2026
$13.5M
Transnational Research Imaging Core (TRI)P30GM131959 · NIGMS · CLEMSON UNIVERSITY · PI VYAVAHARE, NAREN R · 2019 to 2023
$5.9M
Mechanisms of Long-term Arsenic Exposure on Stem Cells.R15ES027651 · NIEHS · CLEMSON UNIVERSITY · PI BAIN, LISA J · 2017 to 2017
$366k
NIEHS NIH HHS ES027651NIEHS NIH HHS R15 ES027651NIGMS NIH HHS GM131959NIGMS NIH HHS P20 GM146584NIGMS NIH HHS P30 GM131959
6 · The paper itself

Abstract

Arsenic exposure during embryogenesis can lead to improper neurodevelopment and changes in locomotor activity. Additionally, in vitro studies have shown that arsenic inhibits the differentiation of sensory neurons and skeletal muscle. In the current study, human-induced pluripotent stem (iPS) cells were differentiated into motor neurons over 28 days, while being exposed to up to 0.5 μM arsenic. On day 6, neuroepithelial progenitor cells (NEPs) exposed to arsenic had reduced transcript levels of the neural progenitor/stem cell marker nestin (

Indexed as

arsenicChATcholinergic synapsehuman induced pluripotent stem cellsmotor neurons

Identifiers

PMID37624150
PMCPMC10458826
OpenAlexW4385321559

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.