Evidence map›Paper›PMID 37624890›Full record

ArticleScience advances2023

Exposure of volunteers to microgravity by dry immersion bed over 21 days results in gene expression changes and adaptation of T cells.

Carlos J Gallardo-Dodd, Christian Oertlin, Julien Record, Rômulo G Galvani, Christian Sommerauer, Nikolai V Kuznetsov, Evangelos Doukoumopoulos, Liaqat Ali, Mariana M S Oliveira, Christina Seitz and 14 more

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. An Update on Neuroaging on Earth and in Spaceflight.International journal of molecular sciences · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 4 institutions in 4 countries.

Carlos J Gallardo-DoddDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-6086-0550
Christian OertlinDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0001-8913-6358
Julien RecordDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0003-1138-2916
Rômulo G GalvaniDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-2946-375X
Christian SommerauerDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0001-7132-7172
Nikolai V KuznetsovDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0003-3010-3927
Evangelos DoukoumopoulosDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
Liaqat AliProgram in Biology, Division of Science and Mathematics, New York University Abu Dhabi (NYUAD), Abu Dhabi, United Arab Emirates.
Mariana M S OliveiraDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0003-1268-1213
Christina SeitzDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
Mathias PercipalleDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.ORCID 0009-0006-4081-1571
Tijana NikićDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
Anastasia A SadovaRussian Federation State Research Center Institute of Biomedical Problems RAS, Moscow, Russia.ORCID 0000-0002-7633-9460
Sofia M ShulginaRussian Federation State Research Center Institute of Biomedical Problems RAS, Moscow, Russia.ORCID 0000-0002-3476-379X
Vjacheslav A ShmarovRussian Federation State Research Center Institute of Biomedical Problems RAS, Moscow, Russia.ORCID 0000-0001-7156-3415
Olga V KutkoRussian Federation State Research Center Institute of Biomedical Problems RAS, Moscow, Russia.ORCID 0000-0002-5522-7777
Daria D VlasovaRussian Federation State Research Center Institute of Biomedical Problems RAS, Moscow, Russia.
Kseniya D OrlovaRussian Federation State Research Center Institute of Biomedical Problems RAS, Moscow, Russia.ORCID 0000-0002-8021-1814
Marina P RykovaRussian Federation State Research Center Institute of Biomedical Problems RAS, Moscow, Russia.ORCID 0000-0002-9121-5351
John AnderssonInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0003-2799-6349
Piergiorgio PercipalleProgram in Biology, Division of Science and Mathematics, New York University Abu Dhabi (NYUAD), Abu Dhabi, United Arab Emirates.ORCID 0000-0002-9546-7425
Claudia KutterDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-8047-0058
Sergey A PonomarevRussian Federation State Research Center Institute of Biomedical Problems RAS, Moscow, Russia.ORCID 0000-0002-5364-7815
Lisa S WesterbergDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0003-2943-2192
Karolinska Institutet · SEInstitute of Biomedical Problems · RUScience for Life Laboratory · SENew York University Abu Dhabi · AE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The next steps of deep space exploration are manned missions to Moon and Mars. For safe space missions for crew members, it is important to understand the impact of space flight on the immune system. We studied the effects of 21 days dry immersion (DI) exposure on the transcriptomes of T cells isolated from blood samples of eight healthy volunteers. Samples were collected 7 days before DI, at day 7, 14, and 21 during DI, and 7 days after DI. RNA sequencing of CD3

Indexed as

WeightlessnessHumansImmersionT-LymphocytesTranscriptomeVolunteers

Identifiers

PMID37624890
PMCPMC10456848
OpenAlexW4386175523

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.