ArticleScience immunology2023
PD-1 blockade increases the self-renewal of stem-like CD8 T cells to compensate for their accelerated differentiation into effectors.
Open access · greenAbstract read
In one paragraph
Article in Science immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed
11.3field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
62 citing papers in PubMed, 69 citations in OpenAlex.
- Coupling of response biomarkers between tumor and peripheral blood in patients undergoing chemoimmunotherapy.Cell reports. Medicine · 2025Trial
- Progenitor T cells drive chronic pulmonary type 2 inflammation.Nature immunology · 2026Article
- PD-1 regulates CD4Nature communications · 2026Article
- Radiotherapy and immunotherapy in cancer treatment: mechanisms of clinical synergy.The Journal of clinical investigation · 2026Review
- Mechanisms of Therapeutic Resistance and Recent Advances in Glioblastoma Treatment.Immunology and cell biology · 2026Review
- PD-1⁺ CD8⁺ T cells: roles of PD-1 beyond an exhaustion marker.Seminars in immunopathology · 2026Review
- Adaptive resistance in cancer immunotherapy.Cellular & molecular immunology · 2026Review
- New insights into progenitor exhausted T cell populations.Nature reviews. Immunology · 2026Article
- Pre-Encoded IFN-I Sensitivity Exacerbates Memory T Cell Senescence in Solid Tumors.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- GSK-3 regulates CD4-CD8 cooperation for super-armed CD8+ cytolytic T cells in immunotherapy against tumors.Signal transduction and targeted therapy · 2026Article
- The Prognostic Value of the CD8Hematology reports · 2026Article
- Article
- Spatiotemporal immune dynamics in lung cancer progression and treatment.Breathe (Sheffield, England) · 2026Review
- Article
- Vaccination rescues dysfunctional T cell therapy by amplifying rare stem-like antitumor CD8Research square · 2026Article
- From Immunobiology to Clinical Application: Tumor-Infiltrating Lymphocytes in Melanoma.Journal of personalized medicine · 2026Review
- CAR-T cell therapies are coming after glioblastoma: An overview of early phase clinical trials and future perspectives.iScience · 2026Review
- Stepwise differentiation from precursor intermediates and distinct Th1 checkpoints promote CD4 Th1 cell differentiation during chronic viral infection.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Balancing Intrinsic and Extrinsic Factors in CD8Immune network · 2026Review
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 6 institutions in 2 countries.
Amanda L GillEmory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30329, USA.ORCID 0000-0001-5827-8265
Peter H WangDepartment of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA.ORCID 0000-0002-5922-5111
Judong LeeEmory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30329, USA.ORCID 0000-0002-7064-1079
William H HudsonEmory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30329, USA.ORCID 0000-0002-2513-1213
Satomi AndoDivision of Infectious Diseases, Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center, and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
Koichi ArakiDivision of Infectious Diseases, Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center, and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.ORCID 0000-0003-3478-6315
Yinghong HuEmory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30329, USA.
Andreas WielandDepartment of Otolaryngology-Head and Neck Surgery, Ohio State University, Columbus, OH 43210, USA.ORCID 0000-0001-9648-7922
Sejin ImDepartment of Immunology, Sungkyunkwan University School of Medicine, Suwon, Republic of Korea.ORCID 0000-0003-0223-1198
Autumn GavoraEmory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30329, USA.
Christopher B MedinaEmory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30329, USA.ORCID 0000-0001-7441-9232
Gordon J FreemanDepartment of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.ORCID 0000-0002-7210-5616
Masao HashimotoEmory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30329, USA.ORCID 0000-0002-7120-1390
Steven L ReinerDepartment of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA.ORCID 0000-0002-1635-8619
Rafi AhmedEmory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30329, USA.ORCID 0000-0002-9591-2621
Emory University · USCincinnati Children's Hospital Medical Center · USColumbia University · USHarvard University · USSungkyunkwan University · KRThe Ohio State University · US
Funding
Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0MTumor Biology and Microenvironment ProgramP30CA013696 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Anil K Rustgi · 1985 to 2026
$115.3MTransgenic/KnockoutP01AI056299 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI BLAZAR, BRUCE R · 2003 to 2023
$42.5MMedical Scientist Training ProgramT32GM142617 · NIGMS · EMORY UNIVERSITY · PI Jason Yustein · 2022 to 2026
$7.0MT CELL MEMORY TO VIRUSESR01AI030048 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI AHMED, RAFI · 1990 to 2022
$5.2MTranslational Regulation of CD8 T-Cell Immunity - Transfer of R01AI139675 from EmoryR01AI139675 · NIAID · EMORY UNIVERSITY · PI ARAKI, KOICHI · 2018 to 2022
$2.3MStrategies to predict and overcome resistance to cancer immunotherapyR01CA279268 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI STEVEN L REINER · 2023 to 2026
$2.2MColumbia University Graduate Training Program in Microbiology and ImmunologyT32AI106711 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Nicholas Arpaia, Uttiya Basu · 2014 to 2026
$2.1MStructure and Mechanism of Programmed Ribosomal Frameshifting in SARS coronavirusR01AI104711 · NIAID · HARVARD UNIVERSITY · PI D'SOUZA, VICTORIA MANUEL · 2013 to 2017
$1.9MSelf-renewing Lymphocyte Division in The Immune ResponseR56AI076458 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI REINER, STEVEN L · 2014 to 2021
$802kControl of CD8+ T cell exhaustion by novel checkpoint moleculesR00AI153736 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI HUDSON, WILLIAM HARRIS · 2022 to 2023
$498kHoward Hughes Medical Institute GT16001NCI NIH HHS P30 CA013696NCI NIH HHS R01 CA279268NIAID NIH HHS P01 AI056299NIAID NIH HHS R00 AI153736NIAID NIH HHS R01 AI030048NIAID NIH HHS R01 AI104711NIAID NIH HHS R01 AI139675NIAID NIH HHS R56 AI076458NIAID NIH HHS T32 AI106711NIGMS NIH HHS T32 GM142617NIH HHS P51 OD011132
Abstract
PD-1
Indexed as
CD8-Positive T-LymphocytesProgrammed Cell Death 1 ReceptorAnimalsAntibodiesCell DifferentiationDisease Models, AnimalHumansMiceAntibodiesProgrammed Cell Death 1 Receptor
Identifiers
What Socratic holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.