Evidence map›Paper›PMID 37626593›Full record

ArticleBiomedicines2023

The Expression of Epac2 and GluA3 in an Alzheimer's Disease Experimental Model and Postmortem Patient Samples.

Tong Zhang, Nshunge Musheshe, Christina H J T M van der Veen, Helmut W Kessels, Amalia Dolga, Peter De Deyn, Ulrich Eisel, Martina Schmidt

Open access · goldAbstract read
In one paragraph

Article in Biomedicines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Frontiers in cellular neuroscience · 2026
    Review
  3. Amyloid-β-Driven Synaptic Deficits Are Mediated by Synaptic Removal of GluA3-Containing AMPA Receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Tong ZhangDepartment of Molecular Pharmacology, University of Groningen, 9713 AV Groningen, The Netherlands.
Nshunge MushesheDepartment of Molecular Pharmacology, University of Groningen, 9713 AV Groningen, The Netherlands.
Christina H J T M van der VeenDepartment of Molecular Pharmacology, University of Groningen, 9713 AV Groningen, The Netherlands.
Helmut W KesselsSwammerdam Institute for Life Sciences, University of Amsterdam, 1098 XH Amsterdam, The Netherlands.
Amalia DolgaDepartment of Molecular Pharmacology, University of Groningen, 9713 AV Groningen, The Netherlands.ORCID 0000-0001-5400-5614
Peter De DeynDepartment of Neurology and Alzheimer Research Center, University of Groningen, University Medical Center Groningen, 9713 GZ Groningen, The Netherlands.ORCID 0000-0002-2228-2964
Ulrich EiselDepartment of Molecular Neurobiology, Groningen Institute for Evolutionary Life Sciences, University of Groningen, 9747 AG Groningen, The Netherlands.ORCID 0000-0003-4178-0384
Martina SchmidtDepartment of Molecular Pharmacology, University of Groningen, 9713 AV Groningen, The Netherlands.ORCID 0000-0003-3075-0630
University of Groningen · NLUniversity Medical Center Groningen · NLUniversity of Amsterdam · NL

Funding

Alzheimer Nederland WE.03-2019-05
6 · The paper itself

Abstract

Alzheimer's disease (AD) is one of the most prevalent neurodegenerative diseases, characterized by amyloid beta (Aβ) and hyperphosphorylated tau accumulation in the brain. Recent studies indicated that memory retrieval, rather than memory formation, was impaired in the early stage of AD. Our previous study reported that pharmacological activation of hippocampal Epac2 promoted memory retrieval in

Indexed as

AKAP5Alzheimer’s diseaseAMPARsEpac2ERK1/2GluA3PI3K/AktPSD95

Identifiers

PMID37626593
PMCPMC10452319
OpenAlexW4385288885

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.