Evidence map›Paper›PMID 37626833›Full record

ArticleCells2023

MPP8 Governs the Activity of the LIF/STAT3 Pathway and Plays a Crucial Role in the Differentiation of Mouse Embryonic Stem Cells.

Heyao Zhang, Tenghui Yang, Hao Wu, Wen Yi, Chunhong Dai, Xi Chen, Wensheng Zhang, Ying Ye

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Heyao ZhangCam-Su Genomic Resource Center, Medical College of Soochow University, Suzhou 215123, China.
Tenghui YangCam-Su Genomic Resource Center, Medical College of Soochow University, Suzhou 215123, China.
Hao WuCam-Su Genomic Resource Center, Medical College of Soochow University, Suzhou 215123, China.
Wen YiShenzhen Key Laboratory of Gene Regulation and Systems Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen 518055, China.
Chunhong DaiCam-Su Genomic Resource Center, Medical College of Soochow University, Suzhou 215123, China.
Xi ChenShenzhen Key Laboratory of Gene Regulation and Systems Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen 518055, China.
Wensheng ZhangCam-Su Genomic Resource Center, Medical College of Soochow University, Suzhou 215123, China.ORCID 0000-0002-6876-3173
Ying YeCam-Su Genomic Resource Center, Medical College of Soochow University, Suzhou 215123, China.
Soochow University · CNSouthern University of Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mouse embryonic stem cells (mESCs) possess the remarkable characteristics of unlimited self-renewal and pluripotency, which render them highly valuable for both fundamental research and clinical applications. A comprehensive understanding of the molecular mechanisms underlying mESC function is of the utmost importance. The Human Silence Hub (HUSH) complex, comprising FAM208A, MPP8, and periphilin, constitutes an epigenetic silencing complex involved in suppressing retroviruses and transposons during early embryonic development. However, its precise role in regulating mESC pluripotency and differentiation remains elusive. In this study, we generated homogenous miniIAA7-tagged

Indexed as

Embryonic DevelopmentMouse Embryonic Stem CellsAnimalsCell DifferentiationCell LineFemaleHumansMicePhosphoproteinsPregnancyProteolysisSTAT3 Transcription FactorMphosph8 protein, mousePhosphoproteinsSTAT3 protein, humanSTAT3 Transcription FactordifferentiationLIF/STAT3 signaling pathwaymESCsMPP8Nanog

Identifiers

PMID37626833
PMCPMC10453500
OpenAlexW4385666400

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.