Evidence mapPaperPMID 37627185Full record

ArticleCancers2023

Cardiologist-Performed Baseline Evaluation with an Assessment of Coronary Status for Prostate Cancer Patients Undergoing Androgen Deprivation Therapy: Impact on Newly Diagnosed Coronary Artery Disease.

Maximilien Rogé, Valentine Guimas, Emmanuel Rio, Loïg Vaugier, Tanguy Perennec, Joachim Alexandre, Stéphane Supiot, Elvire Martin Mervoyer

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Maximilien RogéDepartment of Radiation Oncology, Centre Henri Becquerel, 1 Rue d'Amiens, 76000 Rouen, France.ORCID 0000-0002-6440-9951
Valentine GuimasDepartment of Radiation Oncology, Institut de Cancérologie de l'Ouest, Bd. Professeur Jacques Monod, 44800 Saint-Herblain, France.
Emmanuel RioDepartment of Radiation Oncology, Institut de Cancérologie de l'Ouest, Bd. Professeur Jacques Monod, 44800 Saint-Herblain, France.
Loïg VaugierDepartment of Radiation Oncology, Institut de Cancérologie de l'Ouest, Bd. Professeur Jacques Monod, 44800 Saint-Herblain, France.ORCID 0000-0003-0728-0693
Tanguy PerennecDepartment of Radiation Oncology, Institut de Cancérologie de l'Ouest, Bd. Professeur Jacques Monod, 44800 Saint-Herblain, France.
Joachim AlexandreINSERM U1086 ANTICIPE, Normandie Medecine University, UNICAEN, Avenue du Général Harris, 14000 Caen, France.
Stéphane SupiotDepartment of Radiation Oncology, Institut de Cancérologie de l'Ouest, Bd. Professeur Jacques Monod, 44800 Saint-Herblain, France.ORCID 0000-0003-2094-1708
Elvire Martin MervoyerDepartment of Cardio-Oncology, Institut de Cancérologie de l'Ouest, Bd. Professeur Jacques Monod, 44800 Saint-Herblain, France.ORCID 0009-0004-2399-1166
Institut de Cancérologie de l'Ouest · FRCentre Henri BecquerelInserm · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGiven the potential cardiovascular risks of androgen deprivation therapy (ADT), it is essential to identify patients who may be at an increased risk for coronary artery disease (CAD). Despite the recent ESC recommendations, there is no consensus on when to refer a patient to a cardiologist for further evaluation.

objectiveTo report on new diagnoses of CAD in patients with prostate cancer (PCa) requiring ADT who underwent a systematic cardio-onco evaluation with an assessment of their coronary status. DESIGN, SETTING, AND

participantsThis is a retrospective, monocentric study that included patients with PCa who had completed a cardio-onco evaluation with an assessment of their coronary status in the cardio-oncology department at the Western Cancer Institute, Nantes, between January 2019 and August 2022.

interventionThe baseline cardio-onco evaluation included a physical exam, transthoracic echography, and electrocardiogram, followed with a systematic evaluation of their coronary status. OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: The primary objective was to determine the incidence of newly diagnosed CAD. The secondary objective was to evaluate the number of changes in cardiovascular treatment. RESULTS AND LIMITATIONS: Among the 34 patients who underwent cardio-onco evaluation, 7 (20.6%) were diagnosed with CAD, with a median time to diagnosis of 5 months. Most patients were asymptomatic, with one who experienced a myocardial infarction. Of the 27 patients without CAD, 44.4% underwent a therapeutic intervention by the cardiologist, with no cardiac deaths during follow-up. Overall, 55.9% of patients had a therapeutic intervention after the cardio-onco evaluation.

conclusionsThe high incidence of newly diagnosed CAD in asymptomatic patients supports the need for screening for CAD in this population. Further research is needed to determine whether routine screening for CAD in patients receiving ADT would result in significant clinical benefits.

Indexed as

androgen deprivation therapycardiac risk factorcardiac screeningcardiac workupcardio-oncologycoronary artery diseaseprostate cancerstress test

Identifiers

PMID37627185
PMCPMC10452606
OpenAlexW4385955047

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.