Evidence map›Paper›PMID 37627221›Full record

ArticleCancers2023

A Novel Mouse Model of Combined Hepatocellular-Cholangiocarcinoma Induced by Diethylnitrosamine and Loss of

Judit Domènech Omella, Emanuela E Cortesi, Iris Verbinnen, Michiel Remmerie, Hanghang Wu, Francisco J Cubero, Tania Roskams, Veerle Janssens

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Preclinical mouse models for studying cholangiocarcinoma.Liver research (Beijing, China) · 2026
    Review
  3. Article
  4. The utilisation of biliary organoids for biomedical applications.Frontiers in bioengineering and biotechnology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Judit Domènech OmellaLaboratory of Protein Phosphorylation & Proteomics, Department of Cellular & Molecular Medicine, University of Leuven (KU Leuven), 3000 Leuven, Belgium.ORCID 0000-0002-0871-9306
Emanuela E CortesiTranslational Cell & Tissue Research, University of Leuven (KU Leuven), 3000 Leuven, Belgium.
Iris VerbinnenLaboratory of Protein Phosphorylation & Proteomics, Department of Cellular & Molecular Medicine, University of Leuven (KU Leuven), 3000 Leuven, Belgium.
Michiel RemmerieLaboratory of Protein Phosphorylation & Proteomics, Department of Cellular & Molecular Medicine, University of Leuven (KU Leuven), 3000 Leuven, Belgium.
Hanghang WuDepartment of Immunology, Ophthalmology & ENT, Complutense University School of Medicine, 28040 Madrid, Spain.
Francisco J CuberoDepartment of Immunology, Ophthalmology & ENT, Complutense University School of Medicine, 28040 Madrid, Spain.ORCID 0000-0003-1499-650X
Tania RoskamsTranslational Cell & Tissue Research, University of Leuven (KU Leuven), 3000 Leuven, Belgium.
Veerle JanssensLaboratory of Protein Phosphorylation & Proteomics, Department of Cellular & Molecular Medicine, University of Leuven (KU Leuven), 3000 Leuven, Belgium.ORCID 0000-0002-6772-8448
KU Leuven · BEUniversidad Complutense de Madrid · ESUniversitair Ziekenhuis Leuven · BE

Funding

Belgian Foundation Against Cancer FAC-F/2016/822Research Foundation - Flanders 12X4222NResearch Foundation - Flanders 1S15320NResearch Foundation - Flanders 1S77521NResearch Foundation - Flanders G0B0116N
6 · The paper itself

Abstract

Primary liver cancer (PLC) can be classified in hepatocellular (HCC), cholangiocarcinoma (CCA), and combined hepatocellular-cholangiocarcinoma (cHCC-CCA). The molecular mechanisms involved in PLC development and phenotype decision are still not well understood. Complete deletion of

Indexed as

B56δ regulatory subunitc-MYCcombined hepatocellular-cholangiocarcinoma (cHCC-CCA)diethylnitrosamine (DEN)haploinsufficiencyhepatocellular carcinoma (HCC)mouse modelPpp2r5dprotein phosphatase 2A (PP2A)tumor suppressor

Identifiers

PMID37627221
PMCPMC10453342
OpenAlexW4386031809

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.