Evidence map›Paper›PMID 37628138›Full record

ArticleFoods (Basel, Switzerland)2023

Metallothionein-Kidney Bean Polyphenol Complexes Showed Antidiabetic Activity in Type 2 Diabetic Rats by Improving Insulin Resistance and Regulating Gut Microbiota.

Zhaohang Zuo, Weiqiao Pang, Wei Sun, Baoxin Lu, Liang Zou, Dongjie Zhang, Ying Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Foods (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Zhaohang ZuoCollege of Food Science, Heilongjiang Bayi Agricultural University, Daqing 163319, China.
Weiqiao PangCollege of Food Science, Heilongjiang Bayi Agricultural University, Daqing 163319, China.
Wei SunCollege of Food Science, Heilongjiang Bayi Agricultural University, Daqing 163319, China.
Baoxin LuCollege of Food Science, Heilongjiang Bayi Agricultural University, Daqing 163319, China.
Liang ZouKey Laboratory of Coarse Cereal Processing, Ministry of Agriculture and Rural Affairs, Sichuan Engineering & Technology Research Center of Coarse Cereal Industralization, School of Food and Biological Engineering, Chengdu University, Chengdu 610106, China.
Dongjie ZhangCollege of Food Science, Heilongjiang Bayi Agricultural University, Daqing 163319, China.
Ying WangNational Coarse Cereals Engineering Research Center, Daqing 163319, China.
Heilongjiang Bayi Agricultural University · CNMinistry of Agriculture and Rural Affairs · CN

Funding

National Key Research and Development Project of China 2018YFE0206300National Key Research and Development Project of China 2020YFD1001400Research Team Project of Natural Science Foundation of Heilongjiang Province, China TD2020C003The Basic Scientific Research Operating Expenses Projects of Provincial University of Heilongjiang Province ZDZX202106The Opening Project of Key Laboratory of Coarse Cereal Processing of Ministry of Agriculture and Rural Affairs, and Sichuan Engineering and Technology Research Center of Coarse Cereal Indus-tralization, Chengdu University No. 2023CC010
6 · The paper itself

Abstract

Previous studies have shown that interaction between polyphenols and proteins can benefit health, but the mechanism of its antidiabetic effect has not been thoroughly elucidated. Therefore, this study aimed to investigate the impact of the metallothionein (MT)-kidney bean polyphenol complex on the blood glucose levels and gut microbiota of rats with type 2 diabetes mellitus (T2DM) induced by a high-fat diet combined with streptozotocin (STZ). After 7 weeks of intervention, the MT-kidney bean polyphenol complex can significantly improve the loss of body weight, the increase in blood glucose and blood lipids, and insulin resistance caused by T2DM in rats. In addition, it can effectively alleviate the damage to the pancreas and liver in rats. The MT-kidney bean polyphenol complex also significantly increased the concentrations of six short-chain fatty acids (SCFAs) in the intestinal contents of rats, especially acetic acid, propionic acid, and butyric acid (296.03%, 223.86%, and 148.97%, respectively). More importantly, the MT-kidney bean polyphenol complex can significantly reverse intestinal microflora dysbiosis in rats caused by T2DM, increase intestinal microorganism diversity, improve the abundance of various beneficial bacteria, and reshape the gut microbiota. In summary, the hypoglycemic effect of the MT-kidney bean polyphenol complex and its possible mechanism was expounded in terms of blood glucose level, blood lipid level, and gut microbiota, providing a new perspective on the development of the MT-kidney bean polyphenol complex as functional hypoglycemic food.

Indexed as

gut microbiotahypoglycemickidney bean polyphenolsmetallothioneintype 2 diabetes mellitus

Identifiers

PMID37628138
PMCPMC10453533
OpenAlexW4386032490

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.