Evidence map›Paper›PMID 37629268›Full record

ArticleJournal of clinical medicine2023

Evaluation of Retinal Blood Flow in Patients with Monoclonal Gammopathy Using OCT Angiography.

Cecilia Czakó, Dóra Gerencsér, Kitti Kormányos, Klaudia Kéki-Kovács, Orsolya Németh, Gábor Tóth, Gábor László Sándor, Anita Csorba, Achim Langenbucher, Zoltán Zsolt Nagy and 5 more

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In one paragraph

Article in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 80% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 3 countries.

Cecilia CzakóDepartment of Ophthalmology, Semmelweis University, 1085 Budapest, Hungary.
Dóra GerencsérDepartment of Ophthalmology, Semmelweis University, 1085 Budapest, Hungary.
Kitti KormányosDepartment of Ophthalmology, Semmelweis University, 1085 Budapest, Hungary.
Klaudia Kéki-KovácsDepartment of Ophthalmology, Semmelweis University, 1085 Budapest, Hungary.
Orsolya NémethDepartment of Ophthalmology, Markusovszky University Teaching Hospital, 9700 Szombathely, Hungary.
Gábor TóthDepartment of Ophthalmology, Semmelweis University, 1085 Budapest, Hungary.
Gábor László SándorDepartment of Ophthalmology, Semmelweis University, 1085 Budapest, Hungary.
Anita CsorbaDepartment of Ophthalmology, Semmelweis University, 1085 Budapest, Hungary.
Achim LangenbucherExperimental Ophthalmology, Saarland University, 66424 Homburg, Germany.
Zoltán Zsolt NagyDepartment of Ophthalmology, Semmelweis University, 1085 Budapest, Hungary.
Gergely Varga3rd Department of Internal Medicine and Haematology, Semmelweis University, 1085 Budapest, Hungary.ORCID 0000-0001-6875-056X
László GopcsaDepartment of Haematology and Stem Cell-Transplantation, South-Pest Central Hospital-National Institute for Hematology and Infectious Diseases, 1097 Budapest, Hungary.
Gábor MikalaDepartment of Haematology and Stem Cell-Transplantation, South-Pest Central Hospital-National Institute for Hematology and Infectious Diseases, 1097 Budapest, Hungary.ORCID 0000-0003-2204-7398
Illés KovácsDepartment of Ophthalmology, Semmelweis University, 1085 Budapest, Hungary.
Nóra SzentmáryDepartment of Ophthalmology, Semmelweis University, 1085 Budapest, Hungary.
Semmelweis University · HUNational Center for Epidemiology · HUMarkusovszky Egyetemi Oktatókórház · HUSaarland University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMonoclonal gammopathy (MG) is characterized by monoclonal protein overproduction, potentially leading to the development of hyperviscosity syndrome.

objectiveTo assess retinal circulation using optical coherence tomography angiography (OCTA) parameters in patients with monoclonal gammopathy.

methodsOCTA measurements were performed using the Optovue AngioVue system by examining 44 eyes of 27 patients with MG and 62 eyes of 36 control subjects. Superficial and deep retinal capillary vessel density (VD SVP and DVP) in the whole 3 × 3 mm macular and parafoveal area, foveal avascular zone (FAZ) area, and central retinal thickness (CRT) were measured using the AngioAnalytics software. The OCTA parameters were evaluated in both groups using a multivariate regression model, after controlling for the effect of imaging quality (SQ).

resultsThere was no significant difference in age between the subjects with monoclonal gammopathy and the controls (63.59 ± 9.33 vs. 58.01 ± 11.46 years;

conclusionsA decreased superficial retinal capillary vessel density measured using OCTA in patients with MG suggests a slow blood flow, reduced capillary circulation, and consequent tissue hypoperfusion. An evaluation of retinal circulation using OCTA in cases of monoclonal gammopathy may be a sensitive method for the non-invasive detection and follow-up of early microcirculatory dysfunction caused by increased viscosity.

Indexed as

hyperviscosity syndromemonoclonal gammopathymultiple myelomaoptical coherence tomography angiography

Identifiers

PMID37629268
PMCPMC10456010
OpenAlexW4385758583

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.