Evidence mapPaperPMID 37629275Full record

ReviewJournal of clinical medicine2023

Management of Coronary Artery Disease in Older Adults: Recent Advances and Gaps in Evidence.

Stefano Cacciatore, Luigi Spadafora, Marco Bernardi, Mattia Galli, Matteo Betti, Francesco Perone, Giulia Nicolaio, Emanuele Marzetti, Anna Maria Martone, Francesco Landi and 5 more

Open access · goldAbstract readReview
In one paragraph

Review in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
13.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.

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  9. [Medical image segmentation method based on self-attention and multi-view attention].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 11 institutions in 4 countries.

Stefano CacciatoreDepartment of Geriatrics, Orthopedics and Rheumatology, Università Cattolica del Sacro Cuore, Largo F. Vito 1, 00168 Rome, Italy.ORCID 0000-0001-7504-3775
Luigi SpadaforaDepartment of Clinical, Internal Medicine, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico 155, 00186 Rome, Italy.ORCID 0000-0001-6443-4121
Marco BernardiDepartment of Clinical, Internal Medicine, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico 155, 00186 Rome, Italy.ORCID 0000-0001-9269-8829
Mattia GalliMaria Cecilia Hospital, GVM Care & Research, 48033 Cotignola, Italy.
Matteo BettiUniversity of Milan, 20122, Milan, Italy.ORCID 0009-0008-8458-3747
Francesco PeroneCardiac Rehabilitation Unit, Rehabilitation Clinic "Villa delle Magnolie", 81020 Castel Morrone, Caserta, Italy.ORCID 0000-0002-1418-7908
Giulia NicolaioDepartment of Experimental and Clinical Medicine and Geriatrics, University of Florence, Azienda Ospedaliero Universitaria Careggi, Largo Giovanni Alessandro Brambilla 3, 50134 Florence, Italy.
Emanuele MarzettiDepartment of Geriatrics, Orthopedics and Rheumatology, Università Cattolica del Sacro Cuore, Largo F. Vito 1, 00168 Rome, Italy.ORCID 0000-0001-9567-6983
Anna Maria MartoneFondazione Policlinico Universitario "Agostino Gemelli" IRCCS, Largo A. Gemelli 8, 00168 Rome, Italy.
Francesco LandiDepartment of Geriatrics, Orthopedics and Rheumatology, Università Cattolica del Sacro Cuore, Largo F. Vito 1, 00168 Rome, Italy.
Elad AsherThe Jesselson Integrated Heart Center, Shaare Zedek Medical Center, Faculty of Medicine, Hebrew University, P.O. Box 12271, Jerusalem 9112102, Israel.ORCID 0000-0003-3381-605X
Maciej BanachDepartment of Preventive Cardiology, Polish Mother's Memorial Hospital Research Institute (PMMHRI), Medical University of Lodz (MUL), 93-338 Lodz, Poland.ORCID 0000-0001-6690-6874
Olivier HanonAssistance Publique Hôpitaux de Paris, Geriatric Department, Broca Hospital, University of Paris Cité, 54-56 Rue Pascal, 75013 Paris, France.
Giuseppe Biondi-ZoccaiDepartment of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Corso della Repubblica 79, 04100 Latina, Italy.ORCID 0000-0001-6103-8510
Pierre SabouretHeart Institute, Pitié-Salpétrière Hospital, ACTION-Group, Sorbonne University, 47-83 Bd de l'Hôpital, 75013 Paris, France.ORCID 0000-0002-0243-3673
Università Cattolica del Sacro Cuore · ITPoliclinico Umberto I · ITAgostino Gemelli University Polyclinic · ITAzienda Ospedaliero-Universitaria Careggi · ITClinica Mediterranea · ITMaria Cecilia Hospital · ITMedical University of Lodz · PLShaare Zedek Medical Center · ILSorbonne Université · FRUniversité Paris Cité · FRUniversity of Milan · IT

Funding

Centro Studi Achille e Linda Lorenzon N/AEuropean Commission - NextGeneration EU Age-IT spoke 3European Union - NextGenerationEU M4C2-I1.3 Project PE_00000019 "HEAL ITALIA"Italian Ministry of Health Ricerca Corrente 2023Università Cattolica del Sacro Cuore D1.2020 and D1.2022
6 · The paper itself

Abstract

Coronary artery disease (CAD) is highly prevalent in older adults, yet its management remains challenging. Treatment choices are made complex by the frailty burden of older patients, a high prevalence of comorbidities and body composition abnormalities (e.g., sarcopenia), the complexity of coronary anatomy, and the frequent presence of multivessel disease, as well as the coexistence of major ischemic and bleeding risk factors. Recent randomized clinical trials and epidemiological studies have provided new data on optimal management of complex patients with CAD. However, frail older adults are still underrepresented in the literature. This narrative review aims to highlight the importance of assessing frailty as an aid to guide therapeutic decision-making and tailor CAD management to the specific needs of older adults, taking into account age-related pharmacokinetic and pharmacodynamic changes, polypharmacy, and potential drug interactions. We also discuss gaps in the evidence and offer perspectives on how best in the future to optimize the global strategy of CAD management in older adults.

Indexed as

agedantithrombotic agentscoronary artery diseasefrailtyhemorrhageischemiamultimorbidity

Identifiers

PMID37629275
PMCPMC10455820
OpenAlexW4385758369

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.