Evidence map›Paper›PMID 37629643›Full record

ArticleLife (Basel, Switzerland)2023

Role of Functional Neuroimaging with 123I-MIBG and 123I-FP-CIT in De Novo Parkinson's Disease: A Multicenter Study.

Maria Silvia De Feo, Viviana Frantellizzi, Nicoletta Locuratolo, Arianna Di Rocco, Alessio Farcomeni, Caterina Pauletti, Andrea Marongiu, Julia Lazri, Susanna Nuvoli, Francesco Fattapposta and 2 more

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Article in Life (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Maria Silvia De FeoDepartment of Radiological Sciences, Oncology and Anatomo-Pathology, Sapienza, University of Rome, 00161 Rome, Italy.ORCID 0000-0003-3216-4838
Viviana FrantellizziDepartment of Radiological Sciences, Oncology and Anatomo-Pathology, Sapienza, University of Rome, 00161 Rome, Italy.ORCID 0000-0003-3497-4236
Nicoletta LocuratoloDepartment of Human Neurosciences, Sapienza, University of Rome, 00161 Rome, Italy.
Arianna Di RoccoDepartment of Radiological Sciences, Oncology and Anatomo-Pathology, Sapienza, University of Rome, 00161 Rome, Italy.ORCID 0000-0003-1043-0103
Alessio FarcomeniDepartment of Economics & Finance, University of Rome "Tor Vergata", 00133 Rome, Italy.
Caterina PaulettiDepartment of Human Neurosciences, Sapienza, University of Rome, 00161 Rome, Italy.
Andrea MarongiuDepartment of Medical, Surgical and Experimental Sciences, University of Sassari, 07100 Sassari, Italy.
Julia LazriDepartment of Radiological Sciences, Oncology and Anatomo-Pathology, Sapienza, University of Rome, 00161 Rome, Italy.
Susanna NuvoliDepartment of Medical, Surgical and Experimental Sciences, University of Sassari, 07100 Sassari, Italy.
Francesco FattappostaDepartment of Human Neurosciences, Sapienza, University of Rome, 00161 Rome, Italy.
Giuseppe De VincentisDepartment of Radiological Sciences, Oncology and Anatomo-Pathology, Sapienza, University of Rome, 00161 Rome, Italy.ORCID 0000-0003-4690-1528
Angela SpanuDepartment of Medical, Surgical and Experimental Sciences, University of Sassari, 07100 Sassari, Italy.ORCID 0000-0001-5753-399X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundParkinson's disease is a progressive neurodegenerative disorder, with incidence and prevalence rates of 8-18 per 100,000 people per year and 0.3-1%, respectively. As parkinsonian symptoms do not appear until approximately 50-60% of the nigral DA-releasing neurons have been lost, the impact of routine structural imaging findings is minimal at early stages, making Parkinson's disease an ideal condition for the application of functional imaging techniques. The aim of this multicenter study is to assess whether 123I-FP-CIT (DAT-SPECT), 123I-MIBG (mIBG-scintigraphy) or an association of both exams presents the highest diagnostic accuracy in de novo PD patients.

methods288 consecutive patients with suspected diagnoses of Parkinson's disease or non- Parkinson's disease syndromes were analyzed in the present Italian multicenter retrospective study. All subjects were de novo, drug-naive patients and met the inclusion criteria of having undergone both DAT-SPECT and mIBG-scintigraphy within one month of each other.

resultsThe univariate analysis including age and both mIBG-SPECT and DAT-SPECT parameters showed that the only significant values for predicting Parkinson's disease in our population were eH/M, lH/M, ESS and LSS obtained from mIBG-scintigraphy (

conclusionsmIBG-scintigraphy shows higher diagnostic accuracy in de novo Parkinson's disease patients than DAT-SPECT, so given the superiority of the MIBG study, the combined use of both exams does not appear to be mandatory in the early phase of Parkinson's disease.

Indexed as

123I-FP-CIT123I-MIBGParkinson’s disease

Identifiers

PMID37629643
PMCPMC10455638

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.