Evidence map›Paper›PMID 37630945›Full record

ArticleNanomaterials (Basel, Switzerland)2023

Delivery of Therapeutic miRNA via Plasma-Polymerised Nanoparticles Rescues Diabetes-Impaired Endothelial Function.

Yuen Ting Lam, Bob S L Lee, Juichien Hung, Praveesuda Michael, Miguel Santos, Richard P Tan, Renjing Liu, Steven G Wise

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nanomaterials (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.7field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Yuen Ting LamChronic Diseases Theme, School of Medical Science, University of Sydney, Sydney 2006, Australia.
Bob S L LeeVictor Chang Cardiac Research Institute, Darlinghurst 2010, Australia.
Juichien HungChronic Diseases Theme, School of Medical Science, University of Sydney, Sydney 2006, Australia.
Praveesuda MichaelChronic Diseases Theme, School of Medical Science, University of Sydney, Sydney 2006, Australia.
Miguel SantosChronic Diseases Theme, School of Medical Science, University of Sydney, Sydney 2006, Australia.
Richard P TanChronic Diseases Theme, School of Medical Science, University of Sydney, Sydney 2006, Australia.
Renjing LiuVictor Chang Cardiac Research Institute, Darlinghurst 2010, Australia.
Steven G WiseChronic Diseases Theme, School of Medical Science, University of Sydney, Sydney 2006, Australia.ORCID 0000-0001-7964-819X
The University of Sydney · AUVictor Chang Cardiac Research Institute · AU

Funding

Diabetes Australia Y20G-LAMYNational Health and Medical Research Council APP1162969Sydney Local Health District H21/174585
6 · The paper itself

Abstract

MicroRNAs (miRNAs) are increasingly recognised as key regulators of the development and progression of many diseases due to their ability to modulate gene expression post-translationally. While this makes them an attractive therapeutic target, clinical application of miRNA therapy remains at an early stage and in part is limited by the lack of effective delivery modalities. Here, we determined the feasibility of delivering miRNA using a new class of plasma-polymerised nanoparticles (PPNs), which we have recently isolated and characterised. We showed that PPN-miRNAs have no significant effect on endothelial cell viability in vitro in either normal media or in the presence of high-glucose conditions. Delivery of a miRNA inhibitor targeting miR-503 suppressed glucose-induced miR-503 upregulation and restored the downstream mRNA expression of

Indexed as

angiogenesisdiabetesendothelialischemiamiRNAsnanoparticles

Identifiers

PMID37630945
PMCPMC10459051
OpenAlexW4385978509

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.