Evidence map›Paper›PMID 37631015›Full record

ArticlePharmaceuticals (Basel, Switzerland)2023

Analysis of the Effect of the TRPC4/TRPC5 Blocker, ML204, in Sucrose-Induced Metabolic Imbalance.

Mizael C Araújo, Suzany H S Soczek, Jaqueline P Pontes, Bruno A S Pinto, Lucas M França, Bruna da Silva Soley, Gabriela S Santos, Warlison F de Silva Saminez, Fernanda K M Fernandes, João L do Carmo Lima and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Role of TRP Channels in Metabolism-Related Diseases.International journal of molecular sciences · 2024
    Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 1 country.

Mizael C AraújoPrograma de Pós-Graduação, Universidade CEUMA, São Luís 65075-120, MA, Brazil.ORCID 0000-0002-2720-8181
Suzany H S SoczekPrograma de Pós-Graduação em Biotecnologia Aplicada à Saúde da Criança e do Adolescente, Faculdades Pequeno Príncipe, Curitiba 80230-020, PR, Brazil.ORCID 0000-0002-5624-3920
Jaqueline P PontesPrograma de Pós-Graduação em Ciências da Saúde, Universidade Federal do Maranhão, São Luís 565085-080, MA, Brazil.
Bruno A S PintoDepartamento de Ciências Fisiológicas, Universidade Federal do Maranhão, São Luís 565085-080, MA, Brazil.ORCID 0000-0003-3595-0578
Lucas M FrançaPrograma de Pós-Graduação em Ciências da Saúde, Universidade Federal do Maranhão, São Luís 565085-080, MA, Brazil.ORCID 0000-0002-4412-1539
Bruna da Silva SoleyDepartamento de Farmacologia, Universidade Federal do Paraná, Curitiba 81531-980, PR, Brazil.
Gabriela S SantosPrograma de Pós-Graduação, Universidade CEUMA, São Luís 65075-120, MA, Brazil.ORCID 0000-0003-2947-5133
Warlison F de Silva SaminezPrograma de Pós-Graduação, Universidade CEUMA, São Luís 65075-120, MA, Brazil.
Fernanda K M FernandesPrograma de Pós-Graduação, Universidade CEUMA, São Luís 65075-120, MA, Brazil.
João L do Carmo LimaPrograma de Pós-Graduação em Ciências da Saúde, Universidade Federal do Maranhão, São Luís 565085-080, MA, Brazil.
Daniele Maria-FerreiraPrograma de Pós-Graduação em Biotecnologia Aplicada à Saúde da Criança e do Adolescente, Faculdades Pequeno Príncipe, Curitiba 80230-020, PR, Brazil.ORCID 0000-0001-7992-510X
João F S RodriguesPrograma de Pós-Graduação, Universidade CEUMA, São Luís 65075-120, MA, Brazil.
Nara L M QuintãoPrograma de Pós-Graduação em Ciências Farmacêuticas, Universidade do Vale do Itajai, Itajaí 88302-901, SC, Brazil.
Valério Monteiro-NetoPrograma de Pós-Graduação em Ciências da Saúde, Universidade Federal do Maranhão, São Luís 565085-080, MA, Brazil.ORCID 0000-0003-2868-1314
Antônio M A PaesPrograma de Pós-Graduação em Ciências da Saúde, Universidade Federal do Maranhão, São Luís 565085-080, MA, Brazil.ORCID 0000-0002-3803-9803
Elizabeth S FernandesPrograma de Pós-Graduação em Biotecnologia Aplicada à Saúde da Criança e do Adolescente, Faculdades Pequeno Príncipe, Curitiba 80230-020, PR, Brazil.ORCID 0000-0002-0567-2514
Universidade Federal do Maranhão · BRInstituto de Pesca · BRUniversidade do Vale do Itajaí · BRUniversidade Federal do Paraná · BR

Funding

Coordenação de Aperfeicoamento de Pessoal de Nível Superior Programa Pró-Amazônia; grant number: 3325/2013; finance code 001Fundação de Amparo à Pesquisa e ao Desenvolvimento Científico e Tecnológico do Maranhão grant numbers: IECT-05738/18 to E.S.F.; and ACT-05691/21, and ACT 01784-21 to V.M.-N.INCT-INOVAMED naInstituto de Pesquisa Pelé Pequeno Príncipe naNational Council for Scientific and Technological Development grant numbers: 305676/2019-9 and 408053/2018-6 to E.S.F; 315072/2020-2 to V.M.-N.; and 302195/2022-0 to D.M-F
6 · The paper itself

Abstract

Sugar-induced metabolic imbalances are a major health problem since an excessive consumption of saccharides has been linked to greater obesity rates at a global level. Sucrose, a disaccharide composed of 50% glucose and 50% fructose, is commonly used in the food industry and found in a range of fast, restaurant, and processed foods. Herein, we investigated the effects of a TRPC4/TRPC5 blocker, ML204, in the metabolic imbalances triggered by early exposure to sucrose-enriched diet in mice. TRPC4 and TRPC5 belong to the family of non-selective Ca

Indexed as

fat depositionhepatic steatosishigh sucrose intakemetabolic changesTRPC4 and TRPC5 channels

Identifiers

PMID37631015
PMCPMC10459798
OpenAlexW4385556858

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.