Evidence map›Paper›PMID 37631095›Full record

ArticlePharmaceuticals (Basel, Switzerland)2023

Ancistrocladinium A Induces Apoptosis in Proteasome Inhibitor-Resistant Multiple Myeloma Cells: A Promising Therapeutic Agent Candidate.

Daniela Brünnert, Raina Seupel, Pankaj Goyal, Matthias Bach, Heike Schraud, Stefanie Kirner, Eva Köster, Doris Feineis, Ralf C Bargou, Andreas Schlosser and 2 more

Open access · goldAbstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Jozimine AInternational journal of molecular sciences · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Daniela BrünnertUniversity Hospital of Würzburg, Comprehensive Cancer Center Mainfranken, Translational Oncology, 97080 Würzburg, Germany.ORCID 0000-0003-0870-9578
Raina SeupelInstitute of Organic Chemistry, University of Würzburg, 97074 Würzburg, Germany.
Pankaj GoyalDepartment of Biotechnology, School of Life Sciences, Central University of Rajasthan, Bandar Sindri, Kishangarh 305817, India.
Matthias BachRudolf Virchow Center for Experimental Biomedicine, University of Würzburg, 97080 Würzburg, Germany.
Heike SchraudUniversity Hospital of Würzburg, Comprehensive Cancer Center Mainfranken, Translational Oncology, 97080 Würzburg, Germany.
Stefanie KirnerUniversity Hospital of Würzburg, Comprehensive Cancer Center Mainfranken, Translational Oncology, 97080 Würzburg, Germany.
Eva KösterInstitute of Organic Chemistry, University of Würzburg, 97074 Würzburg, Germany.
Doris FeineisInstitute of Organic Chemistry, University of Würzburg, 97074 Würzburg, Germany.
Ralf C BargouUniversity Hospital of Würzburg, Comprehensive Cancer Center Mainfranken, Translational Oncology, 97080 Würzburg, Germany.
Andreas SchlosserRudolf Virchow Center for Experimental Biomedicine, University of Würzburg, 97080 Würzburg, Germany.
Gerhard BringmannInstitute of Organic Chemistry, University of Würzburg, 97074 Würzburg, Germany.ORCID 0000-0002-3583-5935
Manik ChatterjeeUniversity Hospital of Würzburg, Comprehensive Cancer Center Mainfranken, Translational Oncology, 97080 Würzburg, Germany.
University of Würzburg · DEComprehensive Cancer Center Mainfranken · DECentral University of Rajasthan · IN

Funding

Department of Biotechnology BT/HRD/01/59/2020Department of Biotechnology BT/INF/22/SP44383/2021Deutsche Forschungsgemeinschaft KFO216Indian Council of Medical Research 6/9-7(234)2020/ECD-II
6 · The paper itself

Abstract

The

Indexed as

activating transcription factor 4 (ATF4)ancistrocladinium Aataxia teleagiectasia mutated (ATM)cellular stress responseH2A histone family member X (H2AX)multiple myelomanaphthylisoquinoline alkaloidsproteasome inhibitor resistanceproteasome subunit beta type-5 (PSMB5)RNA splicing

Identifiers

PMID37631095
PMCPMC10459547
OpenAlexW4385987431

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.