Evidence map›Paper›PMID 37631302›Full record

ReviewPharmaceutics2023

Pharmacological Treatments and Therapeutic Drug Monitoring in Patients with Chronic Pain.

Federica De Rosa, Bruno Giannatiempo, Bruno Charlier, Albino Coglianese, Francesca Mensitieri, Giulia Gaudino, Armando Cozzolino, Amelia Filippelli, Ornella Piazza, Fabrizio Dal Piaz and 1 more

Open access · goldAbstract readReview
In one paragraph

Review in Pharmaceutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Federica De RosaDepartment of Medicine, Surgery and Dentistry, Postgraduate School of Clinical Pharmacology and Toxicology, University of Salerno, 84084 Fisciano, Italy.ORCID 0000-0002-5057-4032
Bruno GiannatiempoDepartment of Medicine, Surgery and Dentistry, Postgraduate School of Clinical Pharmacology and Toxicology, University of Salerno, 84084 Fisciano, Italy.
Bruno CharlierDepartment of Medicine, Surgery and Dentistry, Postgraduate School of Clinical Pharmacology and Toxicology, University of Salerno, 84084 Fisciano, Italy.ORCID 0000-0002-5076-3220
Albino CoglianeseUniversity Hospital "San Giovanni di Dio e Ruggi d'Aragona", 84131 Salerno, Italy.
Francesca MensitieriDepartment of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, 84084 Fisciano, Italy.
Giulia GaudinoDepartment of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, 84084 Fisciano, Italy.
Armando CozzolinoDepartment of Medicine, Surgery and Dentistry, Postgraduate School of Clinical Pharmacology and Toxicology, University of Salerno, 84084 Fisciano, Italy.
Amelia FilippelliDepartment of Medicine, Surgery and Dentistry, Postgraduate School of Clinical Pharmacology and Toxicology, University of Salerno, 84084 Fisciano, Italy.ORCID 0000-0002-8235-9118
Ornella PiazzaUniversity Hospital "San Giovanni di Dio e Ruggi d'Aragona", 84131 Salerno, Italy.ORCID 0000-0002-0316-5930
Fabrizio Dal PiazUniversity Hospital "San Giovanni di Dio e Ruggi d'Aragona", 84131 Salerno, Italy.ORCID 0000-0002-8643-5018
Viviana IzzoUniversity Hospital "San Giovanni di Dio e Ruggi d'Aragona", 84131 Salerno, Italy.ORCID 0000-0001-6066-7569
University of Salerno · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pain is an unpleasant sensory and emotional experience that affects every aspect of a patient's life and which may be treated through different pharmacological and non-pharmacological approaches. Analgesics are the drugs most commonly used to treat pain, and in specific situations, the use of opioids may be considered with caution. These drugs, in fact, do not always induce optimal analgesia in patients, and several problems are associated with their use. The purpose of this narrative review is to describe the pharmacological approaches currently used for the management of chronic pain. We review several aspects, from the pain-scale-based methods currently available to assess the type and intensity of pain, to the most frequently administered drugs (non-narcotic analgesics and narcotic analgesics), whose pharmacological characteristics are briefly reported. Overall, we attempt to provide an overview of different pharmacological treatments while also illustrating the relevant guidelines and indications. We then report the strategies that may be used to reduce problems related to opioid use. Specifically, we focus our attention on therapeutic drug monitoring (TDM), a tool that could help clinicians select the most suitable drug and dose to be used for each patient. The actual potential of using TDM to optimize and personalize opioid-based pain treatments is finally discussed based on recent scientific reports.

Indexed as

analgesiaanalgesic drugschronic painmorphineopioidspain controlpain managementrelieftherapeutic drug monitoring

Identifiers

PMID37631302
PMCPMC10457775
OpenAlexW4385607377

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.