Evidence map›Paper›PMID 37631974›Full record

ArticleViruses2023

Genomic and Temporal Analysis of Deletions Correlated to qRT-PCR Dropout in N Gene in Alpha, Delta and Omicron Variants.

Giulia Gatti, Martina Brandolini, Andrea Mancini, Francesca Taddei, Silvia Zannoli, Giorgio Dirani, Martina Manera, Valentina Arfilli, Agnese Denicolò, Anna Marzucco and 8 more

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 2 institutions in 1 country.

Giulia GattiDepartment of Medical and Surgical Sciences (DIMEC)-Alma Mater Studiorum, University of Bologna, 40138 Bologna, Italy.ORCID 0000-0003-1907-8791
Martina BrandoliniDepartment of Medical and Surgical Sciences (DIMEC)-Alma Mater Studiorum, University of Bologna, 40138 Bologna, Italy.
Andrea ManciniUnit of Microbiology, The Greater Romagna Area Hub Laboratory, 47522 Cesena, Italy.
Francesca TaddeiUnit of Microbiology, The Greater Romagna Area Hub Laboratory, 47522 Cesena, Italy.ORCID 0000-0003-2707-2082
Silvia ZannoliUnit of Microbiology, The Greater Romagna Area Hub Laboratory, 47522 Cesena, Italy.
Giorgio DiraniUnit of Microbiology, The Greater Romagna Area Hub Laboratory, 47522 Cesena, Italy.
Martina ManeraUnit of Microbiology, The Greater Romagna Area Hub Laboratory, 47522 Cesena, Italy.
Valentina ArfilliUnit of Microbiology, The Greater Romagna Area Hub Laboratory, 47522 Cesena, Italy.
Agnese DenicolòUnit of Microbiology, The Greater Romagna Area Hub Laboratory, 47522 Cesena, Italy.
Anna MarzuccoUnit of Microbiology, The Greater Romagna Area Hub Laboratory, 47522 Cesena, Italy.
Maria Sofia MontanariUnit of Microbiology, The Greater Romagna Area Hub Laboratory, 47522 Cesena, Italy.
Irene ZaghiUnit of Microbiology, The Greater Romagna Area Hub Laboratory, 47522 Cesena, Italy.
Massimiliano GuerraUnit of Microbiology, The Greater Romagna Area Hub Laboratory, 47522 Cesena, Italy.
Rita TenninaUnit of Laboratory Medicine-Local Health Authority 1 Complex Operative Unit, 67051 L'Aquila, Italy.
Maria Michela MarinoUnit of Microbiology, The Greater Romagna Area Hub Laboratory, 47522 Cesena, Italy.
Laura GrumiroUnit of Microbiology, The Greater Romagna Area Hub Laboratory, 47522 Cesena, Italy.ORCID 0000-0003-2297-3009
Monica CriccaDepartment of Medical and Surgical Sciences (DIMEC)-Alma Mater Studiorum, University of Bologna, 40138 Bologna, Italy.
Vittorio SambriDepartment of Medical and Surgical Sciences (DIMEC)-Alma Mater Studiorum, University of Bologna, 40138 Bologna, Italy.ORCID 0000-0002-5012-7355
Azienda Unità Sanitaria Locale Della Romagna · ITUniversity of Bologna · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Since the first SARS-CoV-2 outbreak, mutations such as single nucleotide polymorphisms (SNPs) and insertion/deletions (INDELs) have changed and characterized the viral genome sequence, structure and protein folding leading to the onset of new variants. The presence of those alterations challenges not only the clinical field but also the diagnostic demand due to failures in gene detection or incompleteness of polymerase chain reaction (PCR) results. In particular, the analysis of understudied genes such as

Indexed as

SARS-CoV-2Coronavirus Nucleocapsid ProteinsCOVID-19COVID-19 TestingGenomicsHumansPhosphoproteinsPolymerase Chain ReactionCoronavirus Nucleocapsid Proteinsnucleocapsid phosphoprotein, SARS-CoV-2Phosphoproteinsdeletionsgene dropoutN geneSARS-CoV-2WG-NGS

Identifiers

PMID37631974
PMCPMC10458892
OpenAlexW4385269456

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.