Evidence map›Paper›PMID 37633268›Full record

ArticleCell2023

Structure of the thrombopoietin-MPL receptor complex is a blueprint for biasing hematopoiesis.

Naotaka Tsutsumi, Zahra Masoumi, Sophie C James, Julie A Tucker, Hauke Winkelmann, William Grey, Lora K Picton, Lucie Moss, Steven C Wilson, Nathanael A Caveney and 5 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
11.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 41 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 4 countries.

Naotaka TsutsumiDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA; Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA; Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8530, Japan. Electronic address: ntsutsumi@okayama-u.ac.jp.
Zahra MasoumiYork Biomedical Research Institute, Department of Biology, University of York, Heslington, York YO10 5DD, UK.
Sophie C JamesYork Biomedical Research Institute, Department of Biology, University of York, Heslington, York YO10 5DD, UK.
Julie A TuckerYork Biomedical Research Institute, Department of Biology, University of York, Heslington, York YO10 5DD, UK.
Hauke WinkelmannDepartment of Biology/Chemistry and Center of Cellular Nanoanalytics, Osnabrück University, 49076 Osnabrück, Germany.
William GreyYork Biomedical Research Institute, Department of Biology, University of York, Heslington, York YO10 5DD, UK.
Lora K PictonDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Lucie MossYork Biomedical Research Institute, Department of Biology, University of York, Heslington, York YO10 5DD, UK.
Steven C WilsonDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Nathanael A CaveneyDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Kevin M JudeDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA; Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.
Cornelius GatiDepartment of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA; Biosciences Division, SLAC National Accelerator Laboratory, Menlo Park, CA 94025, USA.
Jacob PiehlerDepartment of Biology/Chemistry and Center of Cellular Nanoanalytics, Osnabrück University, 49076 Osnabrück, Germany.
Ian S HitchcockYork Biomedical Research Institute, Department of Biology, University of York, Heslington, York YO10 5DD, UK. Electronic address: ian.hitchcock@york.ac.uk.
K Christopher GarciaDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA; Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: kcgarcia@stanford.edu.
University of York · GBHoward Hughes Medical Institute · USStanford University · USOsnabrück University · DESLAC National Accelerator Laboratory · US

Funding

Structure-based engineering of immune cytokine signalingR01AI051321 · NIAID · STANFORD UNIVERSITY · PI Kenan Christopher GARCIA · 2002 to 2026
$5.6M
Structure, function and engineering of immune cytokine receptor signalingR37AI051321 · NIAID · STANFORD UNIVERSITY · PI GARCIA, KENAN CHRISTOPHER · 2013 to 2022
$4.2M
Cancer Research UK 24593Cancer Research UK A24593Medical Research Council MR/X007146/1NIAID NIH HHS R01 AI051321NIAID NIH HHS R37 AI051321
6 · The paper itself

Abstract

Thrombopoietin (THPO or TPO) is an essential cytokine for hematopoietic stem cell (HSC) maintenance and megakaryocyte differentiation. Here, we report the 3.4 Å resolution cryoelectron microscopy structure of the extracellular TPO-TPO receptor (TpoR or MPL) signaling complex, revealing the basis for homodimeric MPL activation and providing a structural rationalization for genetic loss-of-function thrombocytopenia mutations. The structure guided the engineering of TPO variants (TPO

Indexed as

Receptors, ThrombopoietinThrombopoietinAnimalsCell CycleCryoelectron MicroscopyDNA MethylationHumansMiceThrombopoiesisMPL protein, humanReceptors, ThrombopoietinThrombopoietinc-MPLcryo-EMhematopoiesisJAK-STATligand engineeringmTORsignalingstructurethrombopoietinTpoR

Identifiers

PMID37633268
PMCPMC10528194
OpenAlexW4386171266

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.