ArticleAmerican journal of preventive medicine2024
Fentanyl Concentration in Drug Checking Samples and Risk of Overdose Death in Vancouver, Canada.
Article in American journal of preventive medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Guideline
- Management of opioid use disorder: 2024 update to the national clinical practice guideline.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2024Guideline
- Interpol review of forensic drug chemistry, 2022-2025.Forensic science international. Synergy · 2026Review
- Fentanyl purity and overdose decline: A reexamination of geographic trends.Science advances · 2026Article
- Drug sellers' use of a drug checking service amid the overdose crisis in British Columbia, Canada.Addiction (Abingdon, England) · 2026Article
- Fentanyl Purity and Overdose Decline: A Reexamination of Geographic Trends.medRxiv : the preprint server for health sciences · 2026Article
- Trends in fentanyl-containing drug samples seized by law enforcement agencies across Canada.Addiction (Abingdon, England) · 2026Article
- Temporal and regional associations between fentanyl concentrations in the unregulated drug supply and drug-related mortality in British Columbia, Canada.The International journal on drug policy · 2026Article
- Illicit drug supply, naloxone availability, and overdose mortality in the fentanyl era: a systematic review.Health affairs scholar · 2026Review
- How population-level drug supply data are integrated into health outcomes research: a scoping review.Epidemiologic reviews · 2026Article
- Use of clinic- and community-based overdose prevention services by sex workers who use drugs: findings from a community-based cohort in Vancouver, Canada (2017-2024).Harm reduction journal · 2026Article
- RE-MAKING SELVES AND SOCIAL WORLDS: EXPERIENCES OF LIVE-IN SUBSTANCE USE TREATMENT AMONG ADOLESCENTS EXPERIENCING SOCIAL STRUCTURAL MARGINALIZATION IN VANCOUVER.SSM. Qualitative research in health · 2025Article
- Impact of having a regular drug dealer on obtaining drug checking results consistent with expectations during a drug toxicity crisis in a Canadian setting.Drug and alcohol dependence · 2025Article
- Community-based drug checking at syringe service programs in New York City observe an increasing prevalence of xylazine from 2021 through 2024.Harm reduction journal · 2025Article
- Impacts of the COVID-19 pandemic on supervised consumption service delivery in Vancouver and Surrey, Canada from the perspective of service providers.Discover public health · 2025Article
- "They talk about it like it's an overdose crisis when in fact it's basically genocide": The experiences of Indigenous peoples who use illicit drugs in Vancouver's Downtown Eastside neighbourhood.The International journal on drug policy · 2024Article
- Fentanyl, carfentanil and other fentanyl analogues in Canada's illicit opioid supply: A cross-sectional study.Drug and alcohol dependence reports · 2024Article
- Associations among drug acquisition and use behaviors, psychosocial attributes, and opioid-involved overdoses.BMC public health · 2024Article
- Local Impact From International Crises: Unregulated Drug Toxicity During the COVID-19 Pandemic in British Columbia, Canada.American journal of public health · 2024Article
- Beyond a spec: assessing heterogeneity in the unregulated opioid supply.Harm reduction journal · 2024Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe proliferation of fentanyl and its analogs in illegal, unregulated drug markets remains a major driver of the overdose crisis in North America. Drug checking services have been implemented as a harm reduction strategy to address the crisis. However, little is known about their potential utility as a mechanism for monitoring population-level risk of overdose stemming from changing fentanyl concentration in unregulated drugs over time. Therefore, this study assessed the relationship between median fentanyl concentration in expected opioid drug checking samples and the death rate due to illicit drug toxicity over time in Vancouver, Canada.
methodsMonthly population-based rates of death due to illicit drug toxicity were drawn from provincial coroner records. Monthly median percent fentanyl concentration was calculated using a validated quantification model from point-of-care Fourier-transform infrared spectra among expected opioid samples that tested positive for fentanyl at community drug checking services. A time-series analysis using generalized additive modeling was conducted to examine the association between monthly median fentanyl concentration and monthly death rate due to illicit drug toxicity, controlling for calendar month. Analyses were conducted in 2021-2022.
resultsBetween January 2019 and October 2020, 577 deaths due to illicit drug toxicity occurred in Vancouver, and the observed monthly rate ranged from 1.75 to 7.65 deaths per 100,000 population. A significant, positive association was observed between monthly median fentanyl concentration and monthly death rate due to illicit drug toxicity, adjusting for calendar month (chi-square=52.21, p<0.001).
conclusionsFindings suggest a role for point-of-care drug checking as a tool for monitoring evolving overdose risk at the population level.
Indexed as
Identifiers
37633426What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.