ArticleEuropean heart journal open2023
Aortic flow is associated with aging and exercise capacity.
Article in European heart journal open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT03217240 (Integrated Computational modelIing of Right Heart Mechanics and Blood Flow Dynamics in Congenital Heart Disease), which is not on this map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Integrated Computational modelIing of Right Heart Mechanics and Blood Flow Dynamics in Congenital Heart Disease ("INITIATE")
Who cites it
6 citing papers in PubMed, 12 citations in OpenAlex.
- Clinical 4D flow MRI assessment in aortopathy-what the clinician needs to know.Cardiovascular diagnosis and therapy · 2025Review
- Automated Quantification of Simple and Complex Aortic Flow Using 2D Phase Contrast MRI.Medicina (Kaunas, Lithuania) · 2024Article
- Clinical relevance of aortic conduit and reservoir function.Open heart · 2024Article
- Restoration of flow in the aorta: a novel therapeutic target in aortic valve intervention.Nature reviews. Cardiology · 2024Review
- Cardiac MR modelling of systolic and diastolic blood pressure.Open heart · 2023Article
- Aortic flow is abnormal in HFpEF.Wellcome open research · 2023Article
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
16 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aims: Increased blood flow eccentricity in the aorta has been associated with aortic (AO) pathology, however, its association with exercise capacity has not been investigated. This study aimed to assess the relationships between flow eccentricity parameters derived from 2-dimensional (2D) phase-contrast (PC) cardiovascular magnetic resonance (CMR) imaging and aging and cardiopulmonary exercise test (CPET) in a cohort of healthy subjects. Methods and Results: One hundred and sixty-nine healthy subjects (age 44 ± 13 years, M/F: 96/73) free of cardiovascular disease were recruited in a prospective study (NCT03217240) and underwent CMR, including 2D PC at an orthogonal plane just above the sinotubular junction, and CPET (cycle ergometer) within one week. The following AO flow parameters were derived: AO forward and backward flow indexed to body surface area (FFi, BFi), average flow displacement during systole (FDs Conclusion: AO flow haemodynamics change with aging and predict exercise capacity. Registration: NCT03217240.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.