Evidence map›Paper›PMID 37635984›Full record

ReviewFrontiers in endocrinology2023

The role of glucagon after bariatric/metabolic surgery: much more than an "anti-insulin" hormone.

Gonzalo-Martín Pérez-Arana, Alfredo Díaz-Gómez, José Bancalero-de Los Reyes, Manuel Gracia-Romero, Antonio Ribelles-García, Francisco Visiedo, Álvaro González-Domínguez, David Almorza-Gomar, José-Arturo Prada-Oliveira

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in endocrinology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Gonzalo-Martín Pérez-AranaDepartment of Human Anatomy and Embryology, University of Cadiz, Cádiz, Spain.
Alfredo Díaz-GómezSan Carlos Hospital, Andalusian Health System, Cádiz, Spain.
José Bancalero-de Los ReyesComplejo Hospitalario de Badajoz, Servicio Extremeño de Salud, Cádiz, Spain.
Manuel Gracia-RomeroDepartment of Human Anatomy and Embryology, University of Cadiz, Cádiz, Spain.
Antonio Ribelles-GarcíaDepartment of Human Anatomy and Embryology, University of Cadiz, Cádiz, Spain.
Francisco VisiedoDepartment of Human Anatomy and Embryology, University of Cadiz, Cádiz, Spain.
Álvaro González-DomínguezInstitute for Biomedical Science Research and Innovation (INIBICA), University of Cadiz, Cádiz, Spain.
David Almorza-GomarInstitute for Biomedical Science Research and Innovation (INIBICA), University of Cadiz, Cádiz, Spain.
José-Arturo Prada-OliveiraDepartment of Human Anatomy and Embryology, University of Cadiz, Cádiz, Spain.
Universidad de Cádiz · ESBiomedical Research and Innovation Institute of Cadiz · ESAndalusian Health Service · ESCentro de Implantología Cirugía Oral y Maxilofacial · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The biological activity of glucagon has recently been proposed to both stimulate hepatic glucose production and also include a paradoxical insulinotropic effect, which could suggest a new role of glucagon in the pathophysiology type 2 diabetes mellitus (T2DM). An insulinotropic role of glucagon has been observed after bariatric/metabolic surgery that is mediated through the GLP-1 receptor on pancreatic beta cells. This effect appears to be modulated by other members of the proglucagon family, playing a key role in the beneficial effects and complications of bariatric/metabolic surgery. Glucagon serves a dual role after sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB). In addition to maintaining blood glucose levels, glucagon exhibits an insulinotropic effect, suggesting that glucagon has a more complex function than simply an "anti-insulin hormone".

Indexed as

Bariatric SurgeryDiabetes Mellitus, Type 2GlucagonHumansInsulinProglucagonGlucagonInsulinProglucagonalpha celldiabetesglucagonglucoseincretinRoux-en-Y gastric bypasssleeve gastrectomy

Identifiers

PMID37635984
PMCPMC10451081
OpenAlexW4385758257

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.