Evidence map›Paper›PMID 37636324›Full record

ArticleAnimal cells and systems2023

Chloromethylisothiazolinone induces ER stress-induced stress granule formation in human keratinocytes.

Da-Min Jung, Kee K Kim, Eun-Mi Kim

Open access · goldAbstract read
In one paragraph

Article in Animal cells and systems, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Da-Min JungDepartment of Biochemistry, College of Natural Sciences, Chungnam National University, Daejeon, Republic of Korea.
Kee K KimDepartment of Biochemistry, College of Natural Sciences, Chungnam National University, Daejeon, Republic of Korea.ORCID https://orcid.org/0000-0002-1088-3383
Eun-Mi KimDepartment of Predictive Toxicology, Korea Institute of Toxicology, Daejeon, Republic of Korea.
Chungnam National University · KRKorea Institute of Toxicology · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chloromethylisothiazolinone (CMIT), a humidifier disinfectant, is known to be toxic to the respiratory system. While the toxic effect of CMIT on the lungs has been widely investigated, its effect on the skin is well unknown. In this study, we examined stress granule (SG) formation to investigate the cytotoxic effects of CMIT on human keratinocytes. We assessed the viability of the cells following CMIT exposure and performed immunofluorescence microscopy and immunoblot analyses to determine SG formation and downstream pathways. The IC

Indexed as

ChloromethylisothiazolinoneEndoplasmic reticulum-stressKeratinocyteProtein kinase R-like endoplasmic reticulum kinaseStress granule

Identifiers

PMID37636324
PMCPMC10448836
OpenAlexW4386096460

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.