Evidence map›Paper›PMID 37637115›Full record

ArticleFrontiers in microbiology2023

HTLV-1 p12 modulates the levels of prion protein (PrP

Isabela Silva De Castro, Alessandra Granato, Rafael Meyer Mariante, Marco Antonio Lima, Ana Claudia Celestino Leite, Otávio de Melo Espindola, Cynthia A Pise-Masison, Genoveffa Franchini, Rafael Linden, Juliana Echevarria-Lima

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Molecular characterization of Human T-cell Lymphotropic Viruses 1 and 2 (HTLV-1 and HTLV-2) in samples from blood donation candidates in the state of Pará, Brazilian Amazon.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Isabela Silva De CastroLaboratório de Imunologia Básica e Aplicada, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Alessandra GranatoProgram in Genetics and Genome Biology, Hospital for Sick Children, Toronto, ON, Canada.
Rafael Meyer MarianteLaboratório de Neurogenesis, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Marco Antonio LimaInstituto Nacional de Infectologia Evandro Chagas (INI), Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, Brazil.
Ana Claudia Celestino LeiteInstituto Nacional de Infectologia Evandro Chagas (INI), Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, Brazil.
Otávio de Melo EspindolaInstituto Nacional de Infectologia Evandro Chagas (INI), Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, Brazil.
Cynthia A Pise-MasisonAnimal Models and Retroviral Vaccines Section, Vaccine Branch, National Cancer Institute, Bethesda, MD, United States.
Genoveffa FranchiniAnimal Models and Retroviral Vaccines Section, Vaccine Branch, National Cancer Institute, Bethesda, MD, United States.
Rafael LindenLaboratório de Neurogenesis, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Juliana Echevarria-LimaLaboratório de Imunologia Básica e Aplicada, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Universidade Federal do Rio de Janeiro · BRFundação Oswaldo Cruz · BRNational Cancer Institute · USHospital for Sick Children · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Infection with human T cell lymphotropic virus type 1 (HTLV-1) is endemic in Brazil and is linked with pro-inflammatory conditions including HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), a chronic neuroinflammatory incapacitating disease that culminates in loss of motor functions. The mechanisms underlying the onset and progression of HAM/TSP are incompletely understood. Previous studies have demonstrated that inflammation and infectious agents can affect the expression of cellular prion protein (PrP Methods: Here, we investigated whether HTLV-1 infection affected PrP Results: We found that HTLV-1 infection decreased the expression levels of PrP Discussion: These results suggested that PrP

Indexed as

HTLV-1HTLV-1-infected cellsIFNγlymphocytesp12PrPC

Identifiers

PMID37637115
PMCPMC10449582
OpenAlexW4385728061

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.