Evidence map›Paper›PMID 37637416›Full record

ArticleFrontiers in pharmacology2023

Curcuphenol possesses an unusual histone deacetylase enhancing activity that counters immune escape in metastatic tumours.

Samantha L S Ellis, Sarah Dada, Lilian L Nohara, Iryna Saranchova, Lonna Munro, Cheryl G Pfeifer, Brett A Eyford, Tunc Morova, David E Williams, Ping Cheng and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Samantha L S EllisMichael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada.
Sarah DadaMichael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada.
Lilian L NoharaMichael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada.
Iryna SaranchovaMichael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada.
Lonna MunroMichael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada.
Cheryl G PfeiferMichael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada.
Brett A EyfordMichael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada.
Tunc MorovaVancouver Prostate Centre, Vancouver Coastal Health Research Institute, Vancouver, BC, Canada.
David E WilliamsDepartments of Chemistry and Earth Ocean, and Atmospheric Sciences, University of British Columbia, Vancouver, BC, Canada.
Ping ChengDepartments of Chemistry and Earth Ocean, and Atmospheric Sciences, University of British Columbia, Vancouver, BC, Canada.
Nathan A LackVancouver Prostate Centre, Vancouver Coastal Health Research Institute, Vancouver, BC, Canada.
Raymond J AndersenDepartments of Chemistry and Earth Ocean, and Atmospheric Sciences, University of British Columbia, Vancouver, BC, Canada.
Wilfred A JefferiesMichael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada.
Vancouver Coastal Health · CAUniversity of British Columbia · CAKoç University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Curcuphenol, a common component of the culinary spices, naturally found in marine invertebrates and plants, has been identified as a novel candidate for reversing immune escape by restoring expression of the antigen presentation machinery (APM) in invasive cancers, thereby resurrecting the immune recognition of metastatic tumours. Two synthetic curcuphenol analogues, were prepared by informed design that demonstrated consistent induction of APM expression in metastatic prostate and lung carcinoma cells. Both analogues were subsequently found to possess a previously undescribed histone deacetylase (HDAC)-enhancing activity. Remarkably, the H3K27ac ChIPseq analysis of curcuphenol-treated cells reveals that the induced epigenomic marks closely resemble the changes in genome-wide pattern observed with interferon-γ, a cytokine instrumental for orchestrating innate and adaptive immunity. These observations link dietary components to modifying epigenetic programs that modulate gene expression guiding poised immunity.

Indexed as

antigen processing machinerycurcuphenoldrug discoveryepigenetic modificationHDAChistone deacetylase activitymajor histocompatibility complex class Itumours

Identifiers

PMID37637416
PMCPMC10449465
OpenAlexW4385896775

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.