Evidence map›Paper›PMID 37639608›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

Differential second messenger signaling via dopamine neurons bidirectionally regulates memory retention.

Mai Takakura, Yu Hong Lam, Reiko Nakagawa, Man Yung Ng, Xinyue Hu, Priyanshu Bhargava, Abdalla G Alia, Yuzhe Gu, Zigao Wang, Takeshi Ota and 9 more

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Neuronal Actin Remodeling and Its Role in Higher Nervous Activity.International journal of molecular sciences · 2025
    Review
  2. Review
  3. Article
  4. Review
  5. Cyclic nucleotide-induced bidirectional long-term synaptic plasticity inbioRxiv : the preprint server for biology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 9 institutions in 3 countries.

Mai Takakura *SK Project, Medical Innovation Center, Kyoto University Graduate School of Medicine, Sakyo-ku, Kyoto 606-8507, Japan.
Yu Hong Lam *Division of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, SAR, China.
Reiko NakagawaLaboratory for Cell-Free Protein Synthesis, RIKEN Center for Biosystems Dynamics Research, Kobe 650-0047, Japan.ORCID 0000-0002-6178-2945
Man Yung NgDivision of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, SAR, China.
Xinyue HuDivision of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, SAR, China.
Priyanshu BhargavaDivision of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, SAR, China.ORCID 0000-0003-3598-4890
Abdalla G AliaDivision of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, SAR, China.ORCID 0000-0001-9165-842X
Yuzhe GuDivision of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, SAR, China.
Zigao WangDivision of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, SAR, China.ORCID 0000-0002-7109-0096
Takeshi OtaSHIONOGI & CO., LTD, Analysis and Evaluation Laboratory, Bio Analytical 1, Shionogi Pharmaceutical Research Center, Toyonaka-shi, Osaka 561-0825, Japan.ORCID 0009-0001-1787-5538
Yoko KimuraSK Project, Medical Innovation Center, Kyoto University Graduate School of Medicine, Sakyo-ku, Kyoto 606-8507, Japan.
Nao MorimotoLaboratory of Molecular Cell Biology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Hokkaido 060-0815, Japan.
Fumitaka OsakadaLaboratory of Cellular Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya University, Nagoya, Aichi 464-8601, Japan.ORCID 0000-0002-9078-1458
Ah Young LeeCenter for Epigenomics Research, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, SAR, China.
Danny LeungDivision of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, SAR, China.
Tomoyuki MiyashitaLearning and Memory Project, Tokyo Metropolitan Institute of Medical Science, Kamikitazawa, Setagaya, Tokyo 156-8506, Japan.ORCID 0009-0007-0436-5073
Juan DuDepartment of Entomology, Ministry of Agriculture and Rural Affairs Key Lab of Pest Monitoring and Green Management, College of Plant Protection, China Agricultural University, Beijing 100193, China.ORCID 0000-0002-1850-3613
Hiroyuki OkunoSK Project, Medical Innovation Center, Kyoto University Graduate School of Medicine, Sakyo-ku, Kyoto 606-8507, Japan.
Yukinori HiranoSK Project, Medical Innovation Center, Kyoto University Graduate School of Medicine, Sakyo-ku, Kyoto 606-8507, Japan.
Hong Kong University of Science and Technology · HKKyoto University · JPHokkaido University · JPKagoshima University · JPMinistry of Agriculture and Rural Affairs · CNNagoya University · JPRIKEN Center for Biosystems Dynamics Research · JPShionogi (Japan) · JPTokyo Metropolitan Institute of Medical Science · JP

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
DROSOPHILA GENOMICS RESOURCE CENTERP40OD010949 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Andrew Zelhof · 2012 to 2026
$9.4M
Next-generation Drosophila cell lines to elucidate the cellular basis of human diseasesR24OD019847 · OD · HARVARD MEDICAL SCHOOL · PI PERRIMON, NORBERT, SIMCOX, AMANDA · 2017 to 2020
$2.7M
NIH HHS P40 OD010949NIH HHS P40 OD018537NIH HHS R24 OD019847
6 · The paper itself

Abstract

Memory formation and forgetting unnecessary memory must be balanced for adaptive animal behavior. While cyclic AMP (cAMP) signaling via dopamine neurons induces memory formation, here we report that cyclic guanine monophosphate (cGMP) signaling via dopamine neurons launches forgetting of unconsolidated memory in

Indexed as

Dopaminergic NeuronsProteomicsAnimalsDrosophilaGuanineHistone DemethylasesMemorySecond Messenger SystemsSignal TransductionGuanineHistone DemethylasescGMP signalingDrosophilaforgettinggene expressionmushroom body

Identifiers

PMID37639608
PMCPMC10483633
OpenAlexW4386211824

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.