Evidence map›Paper›PMID 37645923›Full record

ArticlebioRxiv : the preprint server for biology2024

Hyperactivity of mTORC1 and mTORC2-dependent signaling mediate epilepsy downstream of somatic PTEN loss.

Erin R Cullen, Mona Safari, Isabelle Mittelstadt, Matthew C Weston

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Erin R CullenDepartment of Neurological Sciences, Larner College of Medicine, University of Vermont, Burlington VT, 05405, USA.
Mona SafariFralin Biomedical Research Institute at VTC, Center for Neurobiology Research, Roanoke VA, 24016, USA.
Isabelle MittelstadtDepartment of Neurological Sciences, Larner College of Medicine, University of Vermont, Burlington VT, 05405, USA.
Matthew C WestonDepartment of Neurological Sciences, Larner College of Medicine, University of Vermont, Burlington VT, 05405, USA.ORCID 0000-0001-5558-7070
University of Vermont · USBiomedical Research Institute · US

Funding

Vermont Center for Cardiovascular and Brain HealthP20GM135007 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI Diego Adrianzen Herrera · 2020 to 2026
$17.4M
Synaptic changes and hypersynchronous network activity in mTORopathiesR01NS110945 · NINDS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI WESTON, MATTHEW C · 2019 to 2023
$1.7M
NIGMS NIH HHS P20 GM135007NINDS NIH HHS R01 NS110945
6 · The paper itself

Abstract

Gene variants that hyperactivate PI3K-mTOR signaling in the brain lead to epilepsy and cortical malformations in humans. Some gene variants associated with these pathologies only hyperactivate mTORC1, but others, such as

Identifiers

PMID37645923
PMCPMC10462128
OpenAlexW4386011581

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.