Evidence map›Paper›PMID 37645974›Full record

ArticlebioRxiv : the preprint server for biology2023

Double mutation of open syntaxin and UNC-18 P334A leads to excitatory-inhibitory imbalance and impairs multiple aspects of

Mengjia Huang, Ya Wang, Chun Hin Chow, Karolina P Stepien, Karen Indrawinata, Junjie Xu, Peter Argiropoulos, Xiaoyu Xie, Kyoko Sugita, Chi-Wei Tien and 5 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 3 countries.

Mengjia HuangDivision of Experimental & Translational Neuroscience, Krembil Brain Institute, University Health Network, Ontario, M5T 0S8, Canada.
Ya WangKey Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China.
Chun Hin ChowDivision of Experimental & Translational Neuroscience, Krembil Brain Institute, University Health Network, Ontario, M5T 0S8, Canada.
Karolina P StepienDepartments of Biophysics, Biochemistry and Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas, 75390, USA.
Karen IndrawinataDivision of Experimental & Translational Neuroscience, Krembil Brain Institute, University Health Network, Ontario, M5T 0S8, Canada.
Junjie XuDepartments of Biophysics, Biochemistry and Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas, 75390, USA.
Peter ArgiropoulosDivision of Experimental & Translational Neuroscience, Krembil Brain Institute, University Health Network, Ontario, M5T 0S8, Canada.
Xiaoyu XieDivision of Experimental & Translational Neuroscience, Krembil Brain Institute, University Health Network, Ontario, M5T 0S8, Canada.
Kyoko SugitaDonald K. Johnson Eye Institute, University Health Network, Ontario, M5T 0S8, Canada; Department of Ophthalmology & Vision Sciences, University of Toronto, Toronto, Ontario, M5S 1A8, Canada.
Chi-Wei TienDivision of Experimental & Translational Neuroscience, Krembil Brain Institute, University Health Network, Ontario, M5T 0S8, Canada.
Soomin LeeDivision of Experimental & Translational Neuroscience, Krembil Brain Institute, University Health Network, Ontario, M5T 0S8, Canada.
Philippe P MonnierDepartment of Physiology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, M5S 1A8, Canada.
Josep RizoDepartment of Anesthesiology, Dalian Municipal Friendship Hospital, Dalian Medical University, Dalian, Liaoning, China.ORCID 0000-0003-1773-8311
Shangbang GaoKey Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China.ORCID 0000-0001-5431-4628
Shuzo SugitaDivision of Experimental & Translational Neuroscience, Krembil Brain Institute, University Health Network, Ontario, M5T 0S8, Canada.ORCID 0000-0002-9182-873X
University Health Network · CADalian Medical University · CNHuazhong University of Science and Technology · CNThe University of Texas Southwestern Medical Center · US

Funding

Mechanisms of neurotransmitter release and its regulationR35NS097333 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI RIZOREY, JOSE · 2017 to 2024
$7.0M
NINDS NIH HHS R35 NS097333
6 · The paper itself

Abstract

SNARE and Sec/Munc18 proteins are essential in synaptic vesicle exocytosis. Open form t-SNARE syntaxin and UNC-18 P334A are well-studied exocytosis-enhancing mutants. Here we investigate the interrelationship between the two mutations by generating double mutants in various genetic backgrounds in

Identifiers

PMID37645974
PMCPMC10462135
OpenAlexW4386011608

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.