ArticleThe Journal of clinical endocrinology and metabolism2024
Approach to the Patient: Reninoma.
Article in The Journal of clinical endocrinology and metabolism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- An extrarenal renin-producing tumor associated with a 3 cm mature cystic teratoma.JCEM case reports · 2026Article
- Reninoma: An Occult Etiology of Hypertension Requiring Repeated Diagnostic Evaluation and Managed by Tumor Enucleation: A Case Report.Clinical case reports · 2026Article
- Malignant reninoma with pulmonary metastasis and ATRX mutation treated with olaparib: a case report of specialized treatment.Frontiers in immunology · 2026Article
- Spatial transcriptional mapping reveals the molecular characteristics of juxtaglomerular cell tumors.Frontiers in oncology · 2026Article
- Case Report: A case of pediatric reninoma and literatures review.Frontiers in medicine · 2026Article
- Aldosterone: From Essential Tubular Regulator to Pathological Driver-Physiology, Disease, and Therapeutic Advances.International journal of molecular sciences · 2025Review
- Renal juxtaglomerular cell tumor with normal renin activity and potassium level: a case report.Journal of medical case reports · 2025Article
- Surgical Curative Approach for Severe Hypertension in Select Patients With Underrecognized Rare Renal Tumors: A Case Report.Case reports in urology · 2025Article
- Unravelling a mystery of hypokalemic hypertension- a rare case report of a reninoma.BMC endocrine disorders · 2024Article
- Renovascular hypertension following by juxtaglomerular cell tumor: a challenging case with 12-year history of resistant hypertension and hypokalemia.BMC endocrine disorders · 2024Article
- Renal venous sampling assisted the diagnosis of juxtaglomerular cell tumor: a case report and literature review.Frontiers in oncology · 2023Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A reninoma is a functional tumor of afferent arteriolar juxtaglomerular cells that secretes the enzyme renin, leading to hyperactivation of the renin-angiotensin-aldosterone system. Reninoma is a potentially curable cause of pathological secondary hyperaldosteronism that results in often severe hypertension and hypokalemia. The lack of suppression of plasma renin contrasts sharply with the much more common primary aldosteronism, but diagnosis is often prompted by screening for that condition. The major differential diagnosis of reninoma is renovascular hypertension. Fewer than 200 cases of reninoma have been described. Reninomas have been reported across a broad demographic but have a 2:1 predilection for women, often of childbearing age. Aldosterone receptor blockade, angiotensin-converting enzyme inhibitors, or angiotensin receptor blockers offer effective medical management but are contraindicated in pregnancy, so surgical curative resection is ideal. The current optimal imaging and biochemical workup of reninoma and management approach (ideally, tumor excision with subtotal renal resection) are described.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.