Evidence map›Paper›PMID 37650513›Full record

ArticleeLife2023

Divergent regulation of KCNQ1/E1 by targeted recruitment of protein kinase A to distinct sites on the channel complex.

Xinle Zou, Sri Karthika Shanmugam, Scott A Kanner, Kevin J Sampson, Robert S Kass, Henry M Colecraft

Open access · goldAbstract read
In one paragraph

Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Targeting the ICirculation research · 2024
    Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Xinle Zou *Department of Molecular Pharmacology and Therapeutics, Columbia University, New York, United States.
Sri Karthika Shanmugam *Department of Physiology and Cellular Biophysics, Columbia University, New York, United States.
Scott A Kanner *Doctoral Program in Neurobiology and Behavior, Columbia University, New York, United States.
Kevin J SampsonDepartment of Molecular Pharmacology and Therapeutics, Columbia University, New York, United States.
Robert S KassDepartment of Molecular Pharmacology and Therapeutics, Columbia University, New York, United States.
Henry M ColecraftDepartment of Molecular Pharmacology and Therapeutics, Columbia University, New York, United States.ORCID 0000-0002-2340-8899
Columbia University · US

Funding

Tumor Biology and Microenvironment ProgramP30CA013696 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Anil K Rustgi · 1985 to 2026
$115.3M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007367 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI REINER, STEVEN L · 1985 to 2021
$25.1M
L-type channel trafficking and modulation in heartR01HL121253 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Henry M. Colecraft, Steven O Marx · 2014 to 2026
$8.4M
Modulation of KCNQ1 channel activityR01GM109762 · NIGMS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI KASS, ROBERT S, LARSSON, HANS PETER · 2014 to 2022
$3.1M
Ubiquitin Regulation of K Channels in Health and DiseaseR01HL142111 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI COLECRAFT, HENRY M. · 2018 to 2021
$2.3M
Mechanisms of Long QT Syndrome 1 in HeartR01HL122421 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI COLECRAFT, HENRY M. · 2016 to 2019
$1.8M
Becton Dickinson LSR II Analytical Flow CytometerS10RR027050 · NCRR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CLYNES, RAPHAEL A. · 2011 to 2011
$413k
Sculpting the ubiquitin status of KCNQ1 in cardiac health and diseaseF30HL140878 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KANNER, SCOTT A · 2018 to 2020
$121k
NCI NIH HHS P30 CA013696NCRR NIH HHS S10 RR027050NHLBI NIH HHS F30 HL140878NHLBI NIH HHS R01 HL121253NHLBI NIH HHS R01 HL122421NHLBI NIH HHS R01 HL142111NIGMS NIH HHS R01 GM109762NIGMS NIH HHS T32 GM007367
6 · The paper itself

Abstract

The slow delayed rectifier potassium current,

Indexed as

Cyclic AMP-Dependent Protein KinasesKCNQ1 Potassium ChannelAction PotentialsDeath, Sudden, CardiacHumansProteomicsCyclic AMP-Dependent Protein KinasesKCNQ1 Potassium ChannelKCNQ1 protein, humanbiochemistrycell biologychemical biologyinduced proximityion channel regulationion channel traffickingKCNQ1long QT syndromenonephosphorylation

Identifiers

PMID37650513
PMCPMC10499372
OpenAlexW4386306255

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.