ArticleJournal of medicinal chemistry2023
A Novel Brain PET Radiotracer for Imaging Alpha Synuclein Fibrils in Multiple System Atrophy.
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In one paragraph
Article in Journal of medicinal chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 2 pooled it
7.4field-weighted citation impact, top 2% of its field
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Updated Appropriate Use Criteria for Amyloid and Tau PET: A Report from the Alzheimer's Association and Society for Nuclear Medicine and Molecular Imaging Workgroup.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025Pooled it
- Updated appropriate use criteria for amyloid and tau PET: A report from the Alzheimer's Association and Society for Nuclear Medicine and Molecular Imaging Workgroup.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Pooled it
- A Structure-Activity Relationship Study of Alpha Synuclein PET Radiotracer M503-1619.Molecules (Basel, Switzerland) · 2026Article
- From phenotype to biology: a multi-modal roadmap of biofluid, tissue, imaging, and digital biomarkers in Parkinson's disease.Translational neurodegeneration · 2026Review
- PET imaging of alpha-synuclein: from radiotracer design through in vitro and in vivo translation.European journal of nuclear medicine and molecular imaging · 2026Review
- Discordance of Dopaminergic Dysfunction and Subcortical Atrophy by α-Synuclein Status in Sporadic and Genetic Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Machine learning prediction of multiple distinct high-affinity chemotypes for α-synuclein fibrils.Chemical communications (Cambridge, England) · 2026Article
- Nuclear Medicine Imaging Biomarkers in Parkinson's Disease: Past, Present, and Future Directions.Medical sciences (Basel, Switzerland) · 2025Review
- Progress and challenges in sporadic late-onset cerebellar ataxias.Nature reviews. Neurology · 2025Review
- Interactions of Neurodegenerative Disease Positron Emission Tomography Imaging Probe Candidates with the C-Terminus of α-Synuclein Fibrils.Chembiochem : a European journal of chemical biology · 2025Article
- Design, Synthesis and Evaluation of the First 2-Alkynyl(aza)indolePharmaceuticals (Basel, Switzerland) · 2025Article
- Article
- Advances in PET imaging of protein aggregates associated with neurodegenerative disease.Nature reviews. Neurology · 2025Review
- Alpha-synuclein fibril structures cluster into distinct classes.Biophysical journal · 2025Review
- Pilot Study of [Cells · 2025Article
- Discovery ofCells · 2025Article
- Development of Positron Emission Tomography Radiotracers for Imaging α-Synuclein Aggregates.Cells · 2025Review
- Ligands for Protein Fibrils of Amyloid-β, α-Synuclein, and Tau.Chemical reviews · 2025Review
- Development and In Vitro Characterization of [Cells · 2025Article
- Hypometabolic mismatch with atrophy and tau pathology in mixed Alzheimer's and Lewy body disease.Brain : a journal of neurology · 2025Article
Corrections and comments
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Authors and funding
21 authors at 4 institutions in 1 country.
Ho Young KimDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, 1012, 231 S. 34th Street, Philadelphia, Pennsylvania 19104-6323, United States.ORCID 0000-0003-4391-9642
Wai Kit ChiaDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, 1012, 231 S. 34th Street, Philadelphia, Pennsylvania 19104-6323, United States.
Chia-Ju HsiehDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, 1012, 231 S. 34th Street, Philadelphia, Pennsylvania 19104-6323, United States.ORCID 0000-0002-2833-7727
Dinahlee Saturnino GuarinoDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, 1012, 231 S. 34th Street, Philadelphia, Pennsylvania 19104-6323, United States.
Thomas J A GrahamDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, 1012, 231 S. 34th Street, Philadelphia, Pennsylvania 19104-6323, United States.ORCID 0000-0002-3733-4106
Zsofia Lengyel-ZhandDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, 1012, 231 S. 34th Street, Philadelphia, Pennsylvania 19104-6323, United States.
Mark SchneiderDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, 1012, 231 S. 34th Street, Philadelphia, Pennsylvania 19104-6323, United States.
Cosette TomitaDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, 1012, 231 S. 34th Street, Philadelphia, Pennsylvania 19104-6323, United States.
Marshall G LougeeDepartment of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323, United States.
Hee Jong KimDepartment of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6303, United States.
Vinayak V PagarDepartment of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323, United States.
Hsiaoju LeeDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, 1012, 231 S. 34th Street, Philadelphia, Pennsylvania 19104-6323, United States.
Catherine HouDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, 1012, 231 S. 34th Street, Philadelphia, Pennsylvania 19104-6323, United States.ORCID 0000-0001-8905-8492
Benjamin A GarciaDepartment of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6303, United States.ORCID 0000-0002-2306-1207
E James PeterssonDepartment of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323, United States.
Jennifer O'SheaDepartment of Neurology, Washington University School of Medicine, Saint Louis, Missouri 63110-1010, United States.
Paul T KotzbauerDepartment of Neurology, Washington University School of Medicine, Saint Louis, Missouri 63110-1010, United States.
Chester A MathisDepartment of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, United States.
Virginia M-Y LeeCenter for Neurodegenerative Disease Research, Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104-2676, United States.
Kelvin C LukCenter for Neurodegenerative Disease Research, Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104-2676, United States.
Robert H MachDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, 1012, 231 S. 34th Street, Philadelphia, Pennsylvania 19104-6323, United States.ORCID 0000-0002-7645-2869
University of Pennsylvania · USInstitute for Neurodegenerative Disorders · USWashington University in St. Louis · USUniversity of Pittsburgh · US
Funding
Technology and Remote Assessment CoreU19AG063911 · NIA · MAYO CLINIC ROCHESTER · PI ADAM L. BOXER · 2019 to 2026
$120.9MEarly Onset AD Consortium - the LEAD Study (LEADS)U01AG057195 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI APOSTOLOVA, LIANA G, CARRILLO, MARIA C · 2018 to 2023
$70.3MTDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2MMedicinal Chemistry CoreU19NS110456 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI ROBERT H MACH · 2019 to 2026
$44.1MResearch Education ComponentP30AG062422 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Katherine P Rankin · 2019 to 2026
$36.9MShared Resources Core 2: Quantitative Proteomics CoreP01CA196539 · NCI · ROCKEFELLER UNIVERSITY · PI YOUNG, MICHAEL WARREN · 2015 to 2024
$17.6MTraining in Alzheimer’s and Age-Related Neurodegenerative DiseasesT32AG000255 · NIA · UNIVERSITY OF PENNSYLVANIA · PI ALICE S CHEN-PLOTKIN, VIRGINIA M LEE · 1997 to 2026
$12.5MNational Brain and Tissue Resource for Parkinson's Disease and Related DisordersU24NS072026 · NINDS · BANNER SUN HEALTH RESEARCH INSTITUTE · PI BEACH, THOMAS G · 2011 to 2015
$7.8MViral modulation of epitranscriptomic mechanismsR01AI118891 · NIAID · WASHINGTON UNIVERSITY · PI GARCIA, BENJAMIN A, WEITZMAN, MATTHEW D. · 2015 to 2025
$5.4MQuantitative mass spectrometry for comprehending epigenetic mechanisms in a new underlying neurological developmental disorderR01HD106051 · NICHD · WASHINGTON UNIVERSITY · PI Benjamin A Garcia · 2022 to 2026
$2.6MNCI NIH HHS P01 CA196539NIAID NIH HHS R01 AI118891NIA NIH HHS P01 AG019724NIA NIH HHS P30 AG062422NIA NIH HHS T32 AG000255NIA NIH HHS U01 AG057195NIA NIH HHS U19 AG063911NICHD NIH HHS R01 HD106051NIDA NIH HHS HHSN271201800023CNINDS NIH HHS U19 NS110456NINDS NIH HHS U24 NS072026
Abstract
Abnormal α-synuclein (α-syn) aggregation characterizes α-synucleinopathies, including Parkinson's disease (PD) and multiple system atrophy (MSA). However, no suitable positron emission tomography (PET) radiotracer for imaging α-syn in PD and MSA exists currently. Our structure-activity relationship studies identified 4-methoxy-
Indexed as
Alzheimer DiseaseMultiple System AtrophyParkinson Diseasealpha-SynucleinAmyloid beta-PeptidesAnimalsBrainPositron-Emission Tomographyalpha-SynucleinAmyloid beta-Peptides
Identifiers
What Socratic holds
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Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.