Evidence map›Paper›PMID 37653142›Full record

ReviewNature cancer2023

Clinical and translational advances in ovarian cancer therapy.

Panagiotis A Konstantinopoulos, Ursula A Matulonis

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature cancer, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 265 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
265citing papers in PubMed, 4 pooled it
92.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

265 citing papers in PubMed, 4 syntheses or guidelines pooled it, 337 citations in OpenAlex.

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205 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Panagiotis A KonstantinopoulosDana-Farber Cancer Institute, Boston, MA, USA. panagiotis_konstantinopoulos@dfci.harvard.edu.ORCID http://orcid.org/0000-0002-1032-1479
Ursula A MatulonisDana-Farber Cancer Institute, Boston, MA, USA. ursula_matulonis@dfci.harvard.edu.
Dana-Farber Cancer Institute · US

Funding

VectorP30CA006516 · NCI · DANA-FARBER CANCER INSTITUTE · PI Irene M. Ghobrial · 1985 to 2026
$330.6M
Project 2: Combined personal neoantigen-targeting cancer vaccines with immune checkpoint blockade for ovarian cancerP50CA240243 · NCI · DANA-FARBER CANCER INST · PI CASTRO, CESAR M · 2020 to 2024
$11.5M
Targeting CDK7 in CCNE1-amplified Ovarian CancerR01CA258553 · NCI · STANFORD UNIVERSITY · PI NATHANAEL Schiander GRAY, Panagiotis Konstantinopoulos · 2022 to 2026
$3.5M
NCI NIH HHS P30 CA006516NCI NIH HHS R01 CA258553
6 · The paper itself

Abstract

Ovarian cancer is an aggressive disease that is frequently detected at advanced stages and is initially very responsive to platinum-based chemotherapy. However, the majority of patients relapse following initial surgery and chemotherapy, highlighting the urgent need to develop new therapeutic strategies. In this Review, we outline the main therapeutic principles behind the management of newly diagnosed and recurrent epithelial ovarian cancer and discuss the current landscape of targeted and immune-based approaches.

Indexed as

Ovarian NeoplasmsCarcinoma, Ovarian EpithelialFemaleHumansPlatinumPlatinum

Identifiers

PMID37653142
OpenAlexW4386332584

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.