Evidence map›Paper›PMID 37653435›Full record

ArticleJournal of experimental & clinical cancer research : CR2023

Retinoic acid and proteotoxic stress induce AML cell death overcoming stromal cell protection.

Francesca Liccardo, Martyna Śniegocka, Claudia Tito, Alessia Iaiza, Tiziana Ottone, Mariadomenica Divona, Serena Travaglini, Maurizio Mattei, Rosella Cicconi, Selenia Miglietta and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of experimental & clinical cancer research : CR, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
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  6. WTAP and mCellular and molecular life sciences : CMLS · 2024
    Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 1 country.

Francesca LiccardoDepartment of Anatomical, Histological, Forensic Medicine and Orthopedic Sciences, Section of Histology and Medical Embryology, Sapienza University of Rome, Rome, Italy.
Martyna ŚniegockaDepartment of Anatomical, Histological, Forensic Medicine and Orthopedic Sciences, Section of Histology and Medical Embryology, Sapienza University of Rome, Rome, Italy.
Claudia TitoDepartment of Anatomical, Histological, Forensic Medicine and Orthopedic Sciences, Section of Histology and Medical Embryology, Sapienza University of Rome, Rome, Italy.
Alessia IaizaDepartment of Anatomical, Histological, Forensic Medicine and Orthopedic Sciences, Section of Histology and Medical Embryology, Sapienza University of Rome, Rome, Italy.
Tiziana OttoneDepartment of Biomedicine and Prevention, University of Tor Vergata, Rome, Italy.
Mariadomenica DivonaDepartment of Biomedicine and Prevention, University of Tor Vergata, Rome, Italy.
Serena TravagliniDepartment of Biomedicine and Prevention, University of Tor Vergata, Rome, Italy.
Maurizio MatteiDepartment of Biology, University of Tor Vergata, Rome, Italy.
Rosella CicconiCentro Interdipartimentale-CIMETA, University of Tor Vergata, Rome, Italy.
Selenia MigliettaDepartment of Anatomical, Histological, Forensic Medicine and Orthopedics Sciences, Section of Human Anatomy, Sapienza University of Rome, Rome, Italy.
Giuseppe FamiliariDepartment of Anatomical, Histological, Forensic Medicine and Orthopedics Sciences, Section of Human Anatomy, Sapienza University of Rome, Rome, Italy.
Stefania Annarita NottolaDepartment of Anatomical, Histological, Forensic Medicine and Orthopedics Sciences, Section of Human Anatomy, Sapienza University of Rome, Rome, Italy.
Vincenzo PetrozzaDepartment of Medico-Surgical Sciences & Biotechnologies, Center for Biophotonics, Sapienza University of Rome, Latina, Italy.
Luca TamagnoneDepartment of Life Sciences and Public Health, Histology and Embryology Unit, Catholic University of the Sacred Hearth, Rome, Italy.
Maria Teresa VosoDepartment of Biomedicine and Prevention, University of Tor Vergata, Rome, Italy.
Silvia Masciarelli *Department of Anatomical, Histological, Forensic Medicine and Orthopedic Sciences, Section of Histology and Medical Embryology, Sapienza University of Rome, Rome, Italy. silvia.masciarelli@uniroma1.it.
Francesco Fazi *Department of Anatomical, Histological, Forensic Medicine and Orthopedic Sciences, Section of Histology and Medical Embryology, Sapienza University of Rome, Rome, Italy. francesco.fazi@uniroma1.it.ORCID http://orcid.org/0000-0003-2910-7912
Sapienza University of Rome · ITUniversity of Rome Tor Vergata · ITUniversità Cattolica del Sacro Cuore · IT

Funding

Fondazione AIRC per la ricerca sul cancro ETS IG 2018-ID 21406
6 · The paper itself

Abstract

backgroundAcute myeloid leukemia (AML) patients bearing the ITD mutation in the tyrosine kinase receptor FLT3 (FLT3-ITD) present a poor prognosis and a high risk of relapse. FLT3-ITD is retained in the endoplasmic reticulum (ER) and generates intrinsic proteotoxic stress. We devised a strategy based on proteotoxic stress, generated by the combination of low doses of the differentiating agent retinoic acid (R), the proteasome inhibitor bortezomib (B), and the oxidative stress inducer arsenic trioxide (A).

methodsWe treated FLT3-ITD

resultsThe combination RBA exerts strong cytotoxic activity on FLT3-ITD

conclusionsOur findings strengthen our previous work indicating induction of proteotoxic stress as a possible strategy in FLT3-ITD

Indexed as

CytoprotectionTretinoinAnimalsAscorbic AcidCell DeathDisease Models, AnimalHumansMechanotransduction, CellularMiceProteotoxic StressAscorbic AcidTretinoinActin cytoskeletonAMLBone marrow stromal cellsER stressOxidative stressProteotoxic stressTumor microenvironmentYAP

Identifiers

PMID37653435
PMCPMC10469880
OpenAlexW4386330418

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.