Evidence map›Paper›PMID 37658166›Full record

SynthesisClinical research in cardiology : official journal of the German Cardiac Society2024

Efficacy and safety of intravenous beta-blockers in acute atrial fibrillation and flutter is dependent on beta-1 selectivity: a systematic review and meta-analysis of randomised trials.

Madeleine Perrett, Nisha Gohil, Otilia Tica, Karina V Bunting, Dipak Kotecha

Open access · hybridAbstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Clinical research in cardiology : official journal of the German Cardiac Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Landiolol is effective and safe in paediatric supraventricular tachycardia: evidence from a European prospective multicentre open-label phase III study (LANDI-PED).Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Madeleine PerrettInstitute of Cardiovascular Sciences, University of Birmingham, Vincent Drive, Birmingham, B15 2TT, UK.
Nisha GohilInstitute of Cardiovascular Sciences, University of Birmingham, Vincent Drive, Birmingham, B15 2TT, UK.
Otilia TicaInstitute of Cardiovascular Sciences, University of Birmingham, Vincent Drive, Birmingham, B15 2TT, UK.
Karina V BuntingInstitute of Cardiovascular Sciences, University of Birmingham, Vincent Drive, Birmingham, B15 2TT, UK.
Dipak KotechaInstitute of Cardiovascular Sciences, University of Birmingham, Vincent Drive, Birmingham, B15 2TT, UK. d.kotecha@bham.ac.uk.ORCID http://orcid.org/0000-0002-2570-9812
University of Birmingham · GBUniversity Hospitals Birmingham NHS Foundation Trust · GB

Funding

Amomed (now part of the AOP Orphan Group) independent systematic reviewBritish Heart Foundation Accelerator to the University of Birmingham (AA/18/2/34218)British Heart Foundation Career Development Research Fellowship (FS/CDRF/21/21032)British Heart Foundation FS/CDRF/21/21032Horizon 2020 Framework Programme EU/EEPIA Innovative Medicines Initiative (BigData@Heart 116074)Medical Research Council MRC Health Data Research UK (HDRUK/CFC/01)National Institute for Health and Care Research Birmingham Biomedical Research Centre (NIHR203326)UK National Health Service -Data for R&D- Subnational Secure Data Environment programme West Midlands
6 · The paper itself

Abstract

backgroundIntravenous beta-blockers are commonly used to manage patients with acute atrial fibrillation (AF) and atrial flutter (AFl), but the choice of specific agent is often not evidence-based.

methodsA prospectively-registered systematic review and meta-analysis of randomised trials (PROSPERO: CRD42020204772) to compare the safety and efficacy of intravenous beta-blockers against alternative pharmacological agents.

resultsTwelve trials comparing beta-blockers with diltiazem, digoxin, verapamil, anti-arrhythmic drugs and placebo were included, with variable risk of bias and 1152 participants. With high heterogeneity (I

conclusionsAcross all intravenous beta-blockers, there was no difference with other medications for acute heart rate control in atrial fibrillation and flutter. Efficacy and safety may be improved by choosing beta-blockers with higher beta-1 selectivity.

Indexed as

Atrial FibrillationAtrial FlutterHeart RateRandomized Controlled Trials as TopicAcute DiseaseAdministration, IntravenousAdrenergic beta-1 Receptor AntagonistsAdrenergic beta-AntagonistsAnti-Arrhythmia AgentsHumansTreatment OutcomeAdrenergic beta-1 Receptor AntagonistsAdrenergic beta-AntagonistsAnti-Arrhythmia AgentsAcuteAtrial fibrillationAtrial flutterBeta-blockersMeta-analysisSystematic review

Identifiers

PMID37658166
PMCPMC11108934
OpenAlexW4386386420

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.