ArticleBMC women's health2023
Depression score mediate the association between a body shape index and infertility in overweight and obesity females, NHANES 2013-2018.
Article in BMC women's health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed, 14 citations in OpenAlex.
- Unraveling links between lifestyle behaviors and depressive symptoms: a network analysis using NHANES 2007-2018 data.Annals of general psychiatry · 2026Article
- Assessment of anxiety, depression, and sexual dysfunction in women undergoing fertility treatment.Clinical and experimental reproductive medicine · 2025Article
- Obesity-related indices are associated with self-reported infertility in women: findings from the National Health and Nutrition Examination Survey.The Journal of international medical research · 2025Article
- Deciphering the association between the Life's Essential 8 and infertility: insights into depression, inflammation, and metabolic mediation.Frontiers in endocrinology · 2025Article
- Association between A body shape index and bone mineral density in middle-aged and elderly adults: a retrospective analysis of NHANES 2005-2018.Frontiers in endocrinology · 2025Article
- The mediating and joint effects of depression in the association between cardiovascular health and frailty in middle-aged and elderly people: evidence from NHANES.Frontiers in psychiatry · 2025Article
- Fasting blood glucose mediated the association between a body shape index and depression: a cross sectional study from NHANES 2017-2023.Frontiers in nutrition · 2025Article
- Association between the age-adjusted visceral adiposity index (AVAI) and female infertility status: a cross-sectional analysis of the NHANES 2013-2018.Lipids in health and disease · 2024Article
- Association between oxidative balance score and female infertility from the national health and nutrition examination survey 2013-2018.Frontiers in endocrinology · 2024Article
- Exploring the role of vitamin D in cognitive function: mediation by depression with diabetes modulation in older U.S. adults, a NHANES weighted analysis.Frontiers in nutrition · 2024Article
- Associations of exposure to volatile organic compounds with sleep health and potential mediators: analysis of NHANES data.Frontiers in public health · 2024Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOverweight and obese females demonstrate a significantly increased risk of anovulatory infertility. This study aims to investigate whether depression score could mediate the association between a body shape index (ABSI) and infertility, especially in overweight and obese population.
methodsWe included 5431 adult female Americans from the National Health and Nutrition Examination Survey (NHANES, 2013-2018) database. ABSI manifested the body shape using waist circumference, weight, and height. Infertility or fertility status was defined by interviewing female participants aged ≥ 18 through the reproductive health questionnaires. Depression symptoms were assessed using the Patient Health Questionnaire-9 (PHQ-9) with total scores between 0 and 27. To investigate the association of infertility with ABSI and other individual components, survey-weighted multivariable logistic regression was performed. Mediation analysis of PHQ-9 score was conducted to disentangle the pathways that link ABSI to infertility among the NHANES participants.
results596 (10.97%) females were categorized with having infertility among 5431 participants. Participants with infertility showed higher ABSI and PHQ-9 score, appearing greater population proportion with depression symptoms. In the multivariable logistic regression model, ABSI (adjusted odds ratio = 0.14, 95% CI: 0.04 to 0.50) and PHQ-9 (adjusted odds ratio = 1.04, 95% CI: 1.01 to 1.07) were positively associated with infertility. PHQ-9 score was estimated to mediate 0.2% (P = 0.03) of the link between ABSI and infertility in all individuals, but to mediate 13.5% (P < 0.01) of the ABSI-infertility association in overweight and obese adult females.
conclusionThe association between ABSI and infertility seems to be mediated by depression symptoms scored by PHQ-9, especially in those adult females with overweigh and obesity. Future studies should be implemented to further explore this mediator in ABSI-infertility link.
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