Evidence map›Paper›PMID 37660137›Full record

ArticleCommunications chemistry2023

Selective steroidogenic cytochrome P450 haem iron ligation by steroid-derived isonitriles.

Alaina M Richard, Nathan R Wong, Kurt Harris, Reethy Sundar, Emily E Scott, Thomas C Pochapsky

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Alaina M Richard *Chemical Biology Program, University of Michigan, Ann Arbor, 48109, MI, USA.
Nathan R Wong *Dept. of Biochemistry, Brandeis University, 415 South St., Waltham, 02454-9110, MA, USA.
Kurt HarrisDepartment of Medicinal Chemistry, University of Michigan, 428 Church St., Ann Arbor, 48109-1065, MI, USA.
Reethy SundarDept. of Biochemistry, Brandeis University, 415 South St., Waltham, 02454-9110, MA, USA.
Emily E ScottChemical Biology Program, University of Michigan, Ann Arbor, 48109, MI, USA.
Thomas C PochapskyDept. of Biochemistry, Brandeis University, 415 South St., Waltham, 02454-9110, MA, USA. pochapsk@brandeis.edu.ORCID http://orcid.org/0000-0001-8995-1088
Brandeis University · USUniversity of Michigan · US

Funding

A Synchrotron Radiation Structural Biology ResourcesP30GM133894 · NIGMS · STANFORD UNIVERSITY · PI Aina E. Cohen, KEITH O HODGSON · 2020 to 2026
$43.3M
Macromolecular Structure MechanismT32GM007596 · NIGMS · BRANDEIS UNIVERSITY · PI OPRIAN, DANIEL D · 1985 to 2019
$4.5M
Michigan Chemistry-Biology Interface Training ProgramT32GM132046 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Emily E Scott, Wenjing Wang · 2019 to 2026
$4.1M
Structure and dynamics of clinically-relevant cytochrome P450 enzymes - Summer undergraduate research experience supplementR01GM130997 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI POCHAPSKY, THOMAS CHARLES, SCOTT, EMILY E · 2019 to 2022
$1.8M
NIGMS NIH HHS P30 GM133894NIGMS NIH HHS R01 GM130997NIGMS NIH HHS T32 GM007596NIGMS NIH HHS T32 GM132046
6 · The paper itself

Abstract

Alkyl isonitriles, R-NC, have previously been shown to ligate the heme (haem) iron of cytochromes P450 in both accessible oxidation states (ferrous, Fe

Identifiers

PMID37660137
PMCPMC10475101
OpenAlexW4386390803

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.