Evidence map›Paper›PMID 37660740›Full record

ArticleReproductive toxicology (Elmsford, N.Y.)2023

Placental BCRP transporter reduces cadmium accumulation and toxicity in immortalized human trophoblasts.

Ranran Zhang, Lauren Walker, Xia Wen, Cathleen Doherty, Ludwik Gorczyca, Brian Buckley, Emily S Barrett, Lauren M Aleksunes

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Reproductive toxicology (Elmsford, N.Y.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Mycoestrogen Exposure during Pregnancy: Impact of theEnvironmental health perspectives · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Ranran ZhangDepartment of Biostatistics and Epidemiology, Rutgers University, Piscataway, NJ 08854, USA.
Lauren WalkerDepartment of Pharmacology and Toxicology, Rutgers University, Piscataway, NJ 08854, USA.
Xia WenDepartment of Pharmacology and Toxicology, Rutgers University, Piscataway, NJ 08854, USA; Environmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, NJ 08854, USA.
Cathleen DohertyEnvironmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, NJ 08854, USA.
Ludwik GorczycaJoint Graduate Program in Toxicology, Rutgers University, Piscataway, NJ 08854, USA.
Brian BuckleyEnvironmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, NJ 08854, USA.
Emily S BarrettDepartment of Biostatistics and Epidemiology, Rutgers University, Piscataway, NJ 08854, USA; Environmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, NJ 08854, USA.
Lauren M AleksunesDepartment of Pharmacology and Toxicology, Rutgers University, Piscataway, NJ 08854, USA; Environmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, NJ 08854, USA. Electronic address: aleksunes@eohsi.rutgers.edu.
Rutgers, The State University of New Jersey · USEnvironmental and Occupational Health Sciences Institute · US

Funding

Translational Research Support CoreP30ES005022 · NIEHS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI Emily S Barrett · 1988 to 2026
$47.4M
New Jersey Alliance for Clinical Translational Science: NJ ACTSUL1TR003017 · NCATS · RUTGERS BIOMEDICAL/HEALTH SCIENCES-RBHS · PI PANETTIERI, REYNOLD ALEXANDER · 2019 to 2023
$28.9M
TRAINING IN EVIRONMENTAL TOXICOLOGYT32ES007148 · NIEHS · RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK · PI Lauren M Aleksunes · 1987 to 2026
$11.4M
Placental Responses to Environmental Chemicals - Diversity Supplement 2R01ES029275 · NIEHS · RUTGERS, THE STATE UNIV OF N.J. · PI ALEKSUNES, LAUREN M, BARRETT, EMILY S · 2018 to 2022
$3.2M
Mycoestrogen Disposition and Activity in the PlacentaF31ES029794 · NIEHS · RUTGERS, THE STATE UNIV OF N.J. · PI GORCZYCA, LUDWIK JANUSZ · 2018 to 2019
$62k
NCATS NIH HHS UL1 TR003017NIEHS NIH HHS F31 ES029794NIEHS NIH HHS P30 ES005022NIEHS NIH HHS R01 ES029275NIEHS NIH HHS T32 ES007148
6 · The paper itself

Abstract

Cadmium (Cd) is a ubiquitous environmental metal detectable in most pregnant women. Animal and human studies demonstrate that in utero exposure to Cd reduces birth weight and impairs perinatal growth due to placental toxicity. BCRP is a prominent transporter that can efflux xenobiotics from the placenta. This study sought to investigate Cd transport and toxicity in cultured human BeWo trophoblasts with reduced expression and function of the placental barrier transporter BCRP. Knockdown (KD) of BCRP protein expression and function in BeWo trophoblasts increased the intracellular accumulation of Cd by 100% following treatment with 1 μM CdCl

Indexed as

ATP Binding Cassette Transporter, Subfamily G, Member 2Cell SurvivalNeoplasm ProteinsTrophoblastsCadmiumCadmium ChlorideCell LineEnvironmental PollutantsFemaleHumansPlacentaPregnancyABCG2 protein, humanATP Binding Cassette Transporter, Subfamily G, Member 2CadmiumCadmium ChlorideEnvironmental PollutantsNeoplasm ProteinsBCRPBeWoCadmiumEffluxMetalToxicityTransporter

Identifiers

PMID37660740
PMCPMC10591833
OpenAlexW4386366075

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.