Evidence map›Paper›PMID 37662038›Full record

ReviewFrontiers in neurology2023

Neuroinflammatory disorders of the brain and inner ear: a systematic review of auditory function in patients with migraine, multiple sclerosis, and neurodegeneration to support the idea of an innovative 'window of discovery'.

Arianna Di Stadio, Pietro De Luca, Nehzat Koohi, Diego Kaski, Massimo Ralli, Anja Giesemann, Hans-Peter Hartung, Marta Altieri, Daniela Messineo, Athanasia Warnecke and 2 more

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. [Efficacy analysis of anti-migraine therapy for acute low-frequency hearing loss and investigation of its mechanisms].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2025
    Trial
  2. Article
  3. Review
  4. Review
  5. Article
  6. Feline atopic syndrome: An insight into its effects on the central nervous system through vestibular disease.The Canadian veterinary journal = La revue veterinaire canadienne · 2025
    Article
  7. Article
  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 8 institutions in 4 countries.

Arianna Di StadioGF Ingrassia Department, University of Catania, Catania, Italy.
Pietro De LucaHead and Neck Department, San Giovanni-Addolorata Hospital, Rome, Italy.
Nehzat KoohiThe UCL Queen Square Institute of Neurology, London, United Kingdom.
Diego KaskiThe UCL Queen Square Institute of Neurology, London, United Kingdom.
Massimo RalliDepartment of Sense Organs, University Sapienza, Rome, Italy.
Anja GiesemannDepartment of Interventional Neuroradiologie, Hannover Medical School, Hannover, Germany.
Hans-Peter HartungKlinik für Neurologie UKD Heinrich Heine Universität Düsseldorf, Düsseldorf, Germany.
Marta AltieriDepartment of Neurology, University Sapienza, Rome, Italy.
Daniela MessineoDepartment of Radiology and Pathology, University Sapienza, Rome, Italy.
Athanasia WarneckeDepartment of Otolaryngology-Head and Neck Surgery, Hannover Medical School, Hannover, Germany.
Teresa FrohmanDistinguished Senior Fellows (Sabbatical), Laboratory of Neuroimmunology of Professor Lawrence Steinman, Stanford University School of Medicine, Palo Alto, CA, United States.
Elliot M FrohmanDistinguished Senior Fellows (Sabbatical), Laboratory of Neuroimmunology of Professor Lawrence Steinman, Stanford University School of Medicine, Palo Alto, CA, United States.
Sapienza University of Rome · ITMedizinische Hochschule Hannover · DEStanford University · USAzienda Ospedaliera San Giovanni Addolorata · ITHeinrich Heine University Düsseldorf · DEIstituti di Ricovero e Cura a Carattere Scientifico · ITNational Hospital for Neurology and Neurosurgery · GBUniversity College London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Hearing can be impaired in many neurological conditions and can even represent a forme Methods: A systematic review of the literature was performed, searching for papers with case-control studies that analyzed the hearing and migraine function in patients with neuro-inflammatory, neurodegenerative disorders. With data extracted from these papers, the risk of patients with neurological distortion product otoacoustic emission (DPOAE) was then calculated. Results: Patients with neurological disorders (headache, Parkinson's disease, and multiple sclerosis) had a higher risk of having peripheral auditory deficits when compared to healthy individuals. Conclusion: Existing data lend credence to the hypothesis that inflammatory mediators transmitted via fluid exchange across this communication window, thereby represents a key pathobiological mechanism capable of culminating in hearing disturbances associated with neuroimmunological and neuroinflammatory disorders of the nervous system.

Indexed as

CSFheadacheinner earmultiple sclerosisneuroinflammationParkinson’s disease

Identifiers

PMID37662038
PMCPMC10471191
OpenAlexW4385766163

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.