Evidence map›Paper›PMID 37664218›Full record

ArticleAddiction neuroscience2023

Fatty acid-binding protein 5 differentially impacts dopamine signaling independent of sex and environment.

Brittany J Richardson, John Hamilton, Nicole Roeder, Kyriaki Z Thanos, Matthew Marion, Panayotis K Thanos

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Addiction neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Brittany J RichardsonBehavioral Neuropharmacology and Neuroimaging Laboratory on Addictions, Clinical Research Institute on Addictions, Department of Pharmacology and Toxicology, Jacobs School of Medicine and Biosciences, University at Buffalo, 1021 Main Street, Buffalo, NY 14203-1016, USA.
John HamiltonBehavioral Neuropharmacology and Neuroimaging Laboratory on Addictions, Clinical Research Institute on Addictions, Department of Pharmacology and Toxicology, Jacobs School of Medicine and Biosciences, University at Buffalo, 1021 Main Street, Buffalo, NY 14203-1016, USA.
Nicole RoederBehavioral Neuropharmacology and Neuroimaging Laboratory on Addictions, Clinical Research Institute on Addictions, Department of Pharmacology and Toxicology, Jacobs School of Medicine and Biosciences, University at Buffalo, 1021 Main Street, Buffalo, NY 14203-1016, USA.
Kyriaki Z ThanosBehavioral Neuropharmacology and Neuroimaging Laboratory on Addictions, Clinical Research Institute on Addictions, Department of Pharmacology and Toxicology, Jacobs School of Medicine and Biosciences, University at Buffalo, 1021 Main Street, Buffalo, NY 14203-1016, USA.
Matthew MarionBehavioral Neuropharmacology and Neuroimaging Laboratory on Addictions, Clinical Research Institute on Addictions, Department of Pharmacology and Toxicology, Jacobs School of Medicine and Biosciences, University at Buffalo, 1021 Main Street, Buffalo, NY 14203-1016, USA.
Panayotis K ThanosBehavioral Neuropharmacology and Neuroimaging Laboratory on Addictions, Clinical Research Institute on Addictions, Department of Pharmacology and Toxicology, Jacobs School of Medicine and Biosciences, University at Buffalo, 1021 Main Street, Buffalo, NY 14203-1016, USA.
Clinical Research Institute · US

Funding

Prenatal Tobacco and Cannabis Exposure: A Translational StudyR33DA045640 · NIDA · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI EIDEN, RINA D, THANOS, PANAYOTIS K · 2021 to 2023
$999k
Prenatal Tobacco and Cannabis Exposure: A Translational StudyR21DA045640 · NIDA · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI EIDEN, RINA D, THANOS, PANAYOTIS K · 2018 to 2019
$434k
Fatty Acid Binding Protein - Mediated Control of Endocannabinoid Signaling and Drug AddictionR21DA045863 · NIDA · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI HAJ-DAHMANE, SAMIR, THANOS, PANAYOTIS K · 2018 to 2019
$427k
NIDA NIH HHS R21 DA045640NIDA NIH HHS R21 DA045863NIDA NIH HHS R33 DA045640
6 · The paper itself

Abstract

Epidermal/brain fatty acid-binding protein 5 (FABP5) plays an integral role in the intracellular trafficking of bioactive lipids/endocannabinoids and the subsequent initiation of cellular cascades affecting cannabinoid and dopamine (DA) systems. Social isolation (SI) and environmental enrichment (EE) during adolescence have been shown to impact DA signaling, and, specifically, DA transporter (DAT) and receptor levels of DA type 1 (D1) and 2 (D2); however, the relationship between FABP5, environment and DA signaling remains unclear. The present study quantified DAT and DA receptor levels in male/female FABP5-/- and FABP5+/+ mice raised in either SI or EE. Results showed that FABP5-/- mice had 6.09-8.81% greater D1 levels in striatal sub-regions of the caudal brain, independent of sex or environment. D1 levels were 8.03% greater only in the olfactory tubercle of enrichment-reared animals. In summary, these results supported that FABP5 plays an important function in regulating striatal DA signaling, and this may have important implications as a target with therapeutic potential for various psychiatric disorders.

Indexed as

D1 D2 DATDopamine receptorsDopamine transporter proteinEndocannabinoid systemEnriched environmentFatty acid-binding protein 5Social isolation

Identifiers

PMID37664218
PMCPMC10470066
OpenAlexW4383498196

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.