Evidence map›Paper›PMID 37665120›Full record

ArticleeLife2023

A cell wall synthase accelerates plasma membrane partitioning in mycobacteria.

Takehiro Kado, Zarina Akbary, Daisuke Motooka, Ian L Sparks, Emily S Melzer, Shota Nakamura, Enrique R Rojas, Yasu S Morita, M Sloan Siegrist

Open access · goldAbstract read
In one paragraph

Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Journal of bacteriology · 2026
    Article
  2. Review
  3. Article
  4. Loss ofbioRxiv : the preprint server for biology · 2025
    Article
  5. Article
  6. Article
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Takehiro KadoDepartment of Microbiology, University of Massachusetts Amherst, Amherst, United States.ORCID 0000-0001-5419-6123
Zarina AkbaryDepartment of Biology, New York University, New York, United States.
Daisuke MotookaDepartment of Infection Metagenomics, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan.
Ian L SparksDepartment of Microbiology, University of Massachusetts Amherst, Amherst, United States.
Emily S MelzerDepartment of Microbiology, University of Massachusetts Amherst, Amherst, United States.
Shota NakamuraDepartment of Infection Metagenomics, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan.
Enrique R RojasDepartment of Biology, New York University, New York, United States.ORCID 0000-0003-3388-2794
Yasu S Morita *Department of Microbiology, University of Massachusetts Amherst, Amherst, United States.
M Sloan Siegrist *Department of Microbiology, University of Massachusetts Amherst, Amherst, United States.ORCID 0000-0002-8232-3246
University of Massachusetts Amherst · USNew York University · USThe University of Osaka · JP

Funding

CHEMISTRY-BIOLOGY INTERFACE PREDOCTORAL TRAINING GRANTST32GM008515 · NIGMS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI THOMPSON, LYNMARIE K. · 1995 to 2020
$4.3M
Chemistry-Biology Interface Predoctoral Training GrantT32GM139789 · NIGMS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI ERIC Robert STRIETER · 2021 to 2026
$3.4M
Chemical detection of Mycobacterium tuberculosis growth and antibiotic response during infectionDP2AI138238 · NIAID · UNIVERSITY OF MASSACHUSETTS AMHERST · PI SIEGRIST, MARY SLOAN · 2017 to 2017
$2.3M
Exploring mechanical mechanisms of antibiotic resistanceR35GM143057 · NIGMS · NEW YORK UNIVERSITY · PI ROJAS, ENRIQUE · 2021 to 2025
$1.9M
Spatial organization of mycobacterial cell wall biosynthesisR21AI144748 · NIAID · UNIVERSITY OF MASSACHUSETTS AMHERST · PI MORITA, YASU S, SIEGRIST, MARY SLOAN · 2019 to 2020
$423k
Membrane domain dynamics in Mycobacterium tuberculosisR03AI140259 · NIAID · UNIVERSITY OF MASSACHUSETTS AMHERST · PI MORITA, YASU S · 2018 to 2019
$160k
NIAID NIH HHS DP2 AI138238NIAID NIH HHS R03 AI140259NIAID NIH HHS R21 AI144748NIGMS NIH HHS R35 GM143057NIGMS NIH HHS R35GM143057NIGMS NIH HHS T32 GM008515NIGMS NIH HHS T32 GM139789
6 · The paper itself

Abstract

Lateral partitioning of proteins and lipids shapes membrane function. In model membranes, partitioning can be influenced both by bilayer-intrinsic factors like molecular composition and by bilayer-extrinsic factors such as interactions with other membranes and solid supports. While cellular membranes can departition in response to bilayer-intrinsic or -extrinsic disruptions, the mechanisms by which they partition de novo are largely unknown. The plasma membrane of

Indexed as

Benzyl AlcoholCell WallCell MembraneMycobacterium smegmatisBenzyl Alcoholcell biologycell wallinfectious diseasemicrobiologymycobacteriapenicillin-binding proteinplasma membraneTn-seqtransglycosylase

Identifiers

PMID37665120
PMCPMC10547480
OpenAlexW4386407606

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.