Evidence map›Paper›PMID 37668701›Full record

SynthesisJournal of neurology2023

Strokecopilot: a literature-based clinical decision support system for acute ischemic stroke treatment.

Stanislas Demuth, Joris Müller, Véronique Quenardelle, Valérie Lauer, Roxana Gheoca, Malwina Trzeciak, Irène Pierre-Paul, Jérôme De Sèze, Pierre-Antoine Gourraud, Valérie Wolff

Abstract readMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Journal of neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Stanislas DemuthStroke Unit, University Hospital of Strasbourg, Strasbourg, France. stanislas.demuth@chru-strasbourg.fr.ORCID http://orcid.org/0000-0002-2504-5294
Joris MüllerPublic Health Service, University Hospital of Strasbourg, Strasbourg, France.ORCID http://orcid.org/0000-0001-5918-2548
Véronique QuenardelleStroke Unit, University Hospital of Strasbourg, Strasbourg, France.ORCID http://orcid.org/0000-0002-8388-6198
Valérie LauerStroke Unit, University Hospital of Strasbourg, Strasbourg, France.
Roxana GheocaStroke Unit, University Hospital of Strasbourg, Strasbourg, France.ORCID http://orcid.org/0000-0002-3664-1235
Malwina TrzeciakStroke Unit, University Hospital of Strasbourg, Strasbourg, France.
Irène Pierre-PaulStroke Unit, University Hospital of Strasbourg, Strasbourg, France.
Jérôme De SèzeINSERM U1119 Myelin Biopathology, Neuroprotection, and Therapeutic Strategies, Strasbourg, France.ORCID http://orcid.org/0000-0002-7197-7578
Pierre-Antoine GourraudINSERM U1064 Center for Research in Transplantation and Translational Immunology, Nantes University, Nantes, France.ORCID http://orcid.org/0000-0003-1131-9554
Valérie WolffStroke Unit, University Hospital of Strasbourg, Strasbourg, France.ORCID http://orcid.org/0000-0001-6974-2342

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAcute ischemic stroke (AIS) is an immediate emergency whose management is becoming more and more personalized while facing a limited number of neurologists with high expertise. Clinical decision support systems (CDSS) are digital tools leveraging information and artificial intelligence technologies. Here, we present the Strokecopilot project, a CDSS for the management of the acute phase of AIS. It has been designed to support the evidence-based medicine reasoning of neurologists regarding the indications of intravenous thrombolysis (IVT) and endovascular treatments (ET).

methodsReference populations were manually extracted from the field's main guidelines and randomized clinical trials (RCT). Their characteristics were harmonized in a computerized reference database. We developed a web application whose algorithm identifies the reference populations matching the patient's characteristics. It returns the latter's outcomes in a graphical user interface (GUI), whose design has been driven by real-world practices.

resultsStrokecopilot has been released at www.digitalneurology.net . The reference database includes 25 reference populations from 2 guidelines and 15 RCTs. After a request, the reference populations matching the patient characteristics are displayed with a summary and a meta-analysis of their results. The status regarding IVT and ET indications are presented as "in guidelines", "in literature", or "outside literature references". The GUI is updated to provide several levels of explanation. Strokecopilot may be updated as the literature evolves by loading a new version of the reference populations' database.

conclusionStrokecopilot is a literature-based CDSS, developed to support neurologists in the management of the acute phase of AIS.

Indexed as

Brain IschemiaDecision Support Systems, ClinicalIschemic StrokeStrokeFibrinolytic AgentsHumansThrombolytic TherapyTreatment OutcomeFibrinolytic AgentsAcute ischemic strokeClinical decision support systemsEndovascular treatmentIntravenous thrombolysisNeuroinformatics

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.