Evidence map›Paper›PMID 37668940›Full record

ArticleJournal of cancer survivorship : research and practice2025

Changes in physical function in older women with endometrial cancer with or without adjuvant therapy.

Allison M Quick, Eric McLaughlin, Jessica L Krok Schoen, Ashley S Felix, Carolyn J Presley, Elizabeth M Cespedes Feliciano, Aladdin H Shadyab, Su Yon Jung, Juhua Luo, Jennifer J King and 5 more

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of cancer survivorship : research and practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Allison M QuickDepartment of Radiation Oncology, The Ohio State University Medical Center, Columbus, OH, USA. allison.quick@osumc.edu.
Eric McLaughlinCenter for Biostatistics, The Ohio State University, The Ohio State University, Columbus, OH, USA.
Jessica L Krok SchoenDivision of Medical Dietetics and Health Sciences, School of Health and Rehabilitation Sciences, College of Medicine, The Ohio State University, Columbus, OH, USA.
Ashley S FelixDivision of Epidemiology, College of Public Health, The Ohio State University, Columbus, OH, USA.
Carolyn J PresleyDivision of Medical Oncology, Department of Internal Medicine, College of Medicine, The Ohio State University, Columbus, OH, USA.
Elizabeth M Cespedes FelicianoDivision of Research, Kaiser Permanente Northern California, Oakland, CA, USA.
Aladdin H ShadyabHerbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, La Jolla, CA, USA.
Su Yon JungTranslational Sciences Section, School of Nursing, Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA, USA.
Juhua LuoDepartment of Epidemiology and Biostatistics, School of Public Health, Indiana University, Bloomington, IN, USA.
Jennifer J KingUniversity of Arizona Cancer Center, University of Arizona, Tucson, AZ, USA.
Stephen R RappDepartment of Psychiatry & Behavioral Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Samantha WertsDepartment of Health Promotion Sciences, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ, USA.
Rowan T ChlebowskiThe Lundquist Institute, Torrance, CA, USA.
Michelle NaughtonComprehensive Cancer Center, Division of Cancer Prevention and Control, Department of Internal Medicine, College of Medicine, The Ohio State University, Columbus, OH, USA.
Electra PaskettDivision of Epidemiology, College of Public Health, The Ohio State University, Columbus, OH, USA.

Funding

WOMEN'S HEALTH INITIATIVE - CLINICAL COORDINATING CENTER: TASK AREA B - LONG LIFE STUDY VISIT 2 LIMITED HOME VISIT75N92021D00001 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI ANDERSON, GARNET L. · 2021 to 2025
$52.0M
Women's Health Initiative Cancer Survivor CohortUM1CA173642 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI ANDERSON, GARNET L., CAAN, BETTE J · 2013 to 2018
$12.1M
Life and Longevity After Cancer (LILAC): The Women's Health Initiative Cancer Survivor CohortU01CA173642 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI ANDERSON, GARNET L., PASKETT, ELECTRA D. · 2019 to 2023
$7.5M
WOMEN'S HEALTH INITIATIVE (WHI) REGIONAL CENTER (RC): TASK AREA A AND A275N92021D00002 · NHLBI · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI WACTAWSKI-WENDE, JEAN · 2021 to 2025
$6.9M
WOMEN'S HEALTH INITIATIVE (WHI) REGIONAL CENTER (RC) - TO EXERCISE OPTION PERIOD ONE (1) AND REVISE CONTRACT ARTICLES.75N92021D00004 · NHLBI · STANFORD UNIVERSITY · PI STEFANICK, MARCIA · 2021 to 2025
$6.5M
WOMEN'S HEALTH INITIATIVE (WHI) REGIONAL CENTER (RC) - TO EXERCISE OPTION PERIOD ONE (1) AND REVISE CONTRACT ARTICLES.75N92021D00005 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI VITOLINS, MARA · 2021 to 2025
$4.2M
Resiliency among Older Adults Receiving Lung Cancer Treatment: A Supportive Care Intervention StudyK76AG074923 · NIA · OHIO STATE UNIVERSITY · PI PRESLEY, CAROLYN · 2021 to 2025
$1.2M
NCI NIH HHS U01 CA173642NCI NIH HHS UM1 CA173642NHLBI NIH HHS 75N92021D00001NHLBI NIH HHS 75N92021D00002NIH HHS 1K76AG074923-01WHI NIH HHS 75N92021D00004WHI NIH HHS 75N92021D00005
6 · The paper itself

Abstract

objectiveTo evaluate changes in physical function (PF) for older women with endometrial cancer (EC) + / - adjuvant therapy in the Women's Health Initiative Life and Longevity after Cancer cohort. MATERIALS AND

methodsThis study examined women ≥ 70 years of age with EC with available treatment records. Change in PF was measured using the RAND-36 and compared between groups using Wilcoxon rank-sum tests. Multivariable median regression was used to compare the changes in scores while adjusting for confounding variables.

resultsIncluded in the study were 287 women, 150 (52.3%) women who did not receive adjuvant therapy and 137 (47.7%) who received adjuvant therapy. When comparing PF scores, there was a statistically significant difference in the median percent change in functional decline, with a greater decline in those who received adjuvant therapy (- 5.9% [- 23.5 to 0%]) compared to those who did not (0 [- 18.8 to + 6.7%]), p = 0.02). Results were not statistically significant after multivariable adjustment, but women who underwent chemotherapy had a greater percent change (median ∆ - 13.8% [- 35.5 to 0%]) compared to those who received radiation alone (median ∆ - 5.9% [- 31.3 to 0%]) or chemotherapy and radiation (median ∆ - 6.5% [- 25.8 to + 5.7%].

conclusionsOlder women with EC who received adjuvant therapy experienced greater change in PF than those who did not receive adjuvant therapy, particularly women who received chemotherapy. These results were not statistically significant on multivariate analysis. IMPLICATIONS FOR CANCER SURVIVORS: EC survivors may experience changes in PF because of chemotherapy and/or radiation therapy. Additional supportive care may need to be provided to older women to mitigate functional decline.

Indexed as

Cancer SurvivorsEndometrial NeoplasmsAgedAged, 80 and overChemotherapy, AdjuvantFemaleHumansQuality of LifeAdjuvant therapyChemotherapyEndometrial cancerExternal beam radiationFunctional declineFunctional statusLILACOlder womenRadiationRAND-36Vaginal brachytherapyWHIWomen’s Health Initiative

Identifiers

PMID37668940

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.