Evidence map›Paper›PMID 37669943›Full record

ArticleNature communications2023

Neutrophil metalloproteinase driven spleen damage hampers infection control of trypanosomiasis.

Hien Thi Thu Pham, Stefan Magez, Boyoon Choi, Bolortsetseg Baatar, Joohee Jung, Magdalena Radwanska

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 17 citations in OpenAlex.

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  10. Target neutrophil heterogeneity and plasticity in cancer.Journal of hematology & oncology · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Hien Thi Thu PhamLaboratory for Biomedical Research, Department of Environmental Technology, Food Technology and Molecular Biotechnology KR01, Ghent University Global Campus, Incheon, South Korea.ORCID http://orcid.org/0000-0002-7533-3059
Stefan MagezLaboratory for Biomedical Research, Department of Environmental Technology, Food Technology and Molecular Biotechnology KR01, Ghent University Global Campus, Incheon, South Korea.
Boyoon ChoiLaboratory for Biomedical Research, Department of Environmental Technology, Food Technology and Molecular Biotechnology KR01, Ghent University Global Campus, Incheon, South Korea.
Bolortsetseg BaatarLaboratory for Biomedical Research, Department of Environmental Technology, Food Technology and Molecular Biotechnology KR01, Ghent University Global Campus, Incheon, South Korea.ORCID http://orcid.org/0000-0002-5455-5648
Joohee JungDuksung Women's University, Seoul, South Korea.ORCID http://orcid.org/0000-0001-9124-9052
Magdalena RadwanskaLaboratory for Biomedical Research, Department of Environmental Technology, Food Technology and Molecular Biotechnology KR01, Ghent University Global Campus, Incheon, South Korea. magdalena.radwanska@Ugent.be.ORCID http://orcid.org/0000-0002-0797-6001
Vrije Universiteit Brussel · BEDuksung Women's University · KRGhent University · BEGhent University Global Campus · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent blood transcriptomic analysis of rhodesiense sleeping sickness patients has revealed that neutrophil signature genes and activation markers constitute the top indicators of trypanosomiasis-associated inflammation. Here, we show that Trypanosoma brucei infection results in expansion and differentiation of four splenic neutrophil subpopulations, including Mki67

Indexed as

SpleenTrypanosomiasisHumansInfection ControlMetalloproteasesNeutrophilsMetalloproteases

Identifiers

PMID37669943
PMCPMC10480172
OpenAlexW4386444826

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.