Evidence map›Paper›PMID 37670137›Full record

ArticleCommunications biology2023

INPP5E regulates CD3ζ enrichment at the immune synapse by phosphoinositide distribution control.

Tzu-Yuan Chiu, Chien-Hui Lo, Yi-Hsuan Lin, Yun-Di Lai, Shan-Shan Lin, Ya-Tian Fang, Wei-Syun Huang, Shen-Yan Huang, Pei-Yuan Tsai, Fu-Hua Yang and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Regulation of INPP5E in Ciliogenesis, Development, and Disease.International journal of biological sciences · 2025
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 2 countries.

Tzu-Yuan ChiuInstitute of Atomic and Molecular Sciences, Academia Sinica, Taipei, 106319, Taiwan.ORCID http://orcid.org/0000-0001-8702-9268
Chien-Hui LoInstitute of Biochemistry and Molecular Biology, National Yang Ming Chiao Tung University, Taipei, 112304, Taiwan.
Yi-Hsuan LinInstitute of Biochemistry and Molecular Biology, National Yang Ming Chiao Tung University, Taipei, 112304, Taiwan.
Yun-Di LaiInstitute of Biochemistry and Molecular Biology, National Yang Ming Chiao Tung University, Taipei, 112304, Taiwan.
Shan-Shan LinInstitute of Molecular Medicine, National Taiwan University, Taipei, 10002, Taiwan.
Ya-Tian FangInstitute of Atomic and Molecular Sciences, Academia Sinica, Taipei, 106319, Taiwan.
Wei-Syun HuangInstitute of Biochemistry and Molecular Biology, National Yang Ming Chiao Tung University, Taipei, 112304, Taiwan.
Shen-Yan HuangInstitute of Microbiology and Immunology, National Yang Ming Chiao Tung University, Taipei, 112304, Taiwan.
Pei-Yuan TsaiInstitute of Microbiology and Immunology, National Yang Ming Chiao Tung University, Taipei, 112304, Taiwan.
Fu-Hua YangInstitute of Atomic and Molecular Sciences, Academia Sinica, Taipei, 106319, Taiwan.
Weng Man ChongInstitute of Atomic and Molecular Sciences, Academia Sinica, Taipei, 106319, Taiwan.
Yi-Chieh WuGraduate Institute of Toxicology, College of Medicine, National Taiwan University, Taipei, 100233, Taiwan.
Hsing-Chen TsaiGraduate Institute of Toxicology, College of Medicine, National Taiwan University, Taipei, 100233, Taiwan.ORCID http://orcid.org/0000-0002-7057-9084
Ya-Wen LiuInstitute of Molecular Medicine, National Taiwan University, Taipei, 10002, Taiwan.ORCID http://orcid.org/0000-0003-0180-4142
Chia-Lin HsuInstitute of Microbiology and Immunology, National Yang Ming Chiao Tung University, Taipei, 112304, Taiwan.
Jung-Chi LiaoInstitute of Atomic and Molecular Sciences, Academia Sinica, Taipei, 106319, Taiwan. jungchiliao@gmail.com.ORCID http://orcid.org/0000-0002-4323-6318
Won-Jing WangInstitute of Biochemistry and Molecular Biology, National Yang Ming Chiao Tung University, Taipei, 112304, Taiwan. wangwj@nycu.edu.tw.ORCID http://orcid.org/0000-0001-9733-0839
National Yang Ming Chiao Tung University · TWInstitute of Atomic and Molecular Sciences, Academia Sinica · TWNational Taiwan University · TWScripps Research Institute · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The immune synapse, a highly organized structure formed at the interface between T lymphocytes and antigen-presenting cells (APCs), is essential for T cell activation and the adaptive immune response. It has been shown that this interface shares similarities with the primary cilium, a sensory organelle in eukaryotic cells, although the roles of ciliary proteins on the immune synapse remain elusive. Here, we find that inositol polyphosphate-5-phosphatase E (INPP5E), a cilium-enriched protein responsible for regulating phosphoinositide localization, is enriched at the immune synapse in Jurkat T-cells during superantigen-mediated conjugation or antibody-mediated crosslinking of TCR complexes, and forms a complex with CD3ζ, ZAP-70, and Lck. Silencing INPP5E in Jurkat T-cells impairs the polarized distribution of CD3ζ at the immune synapse and correlates with a failure of PI(4,5)P

Indexed as

AntibodiesPhosphoric Monoester HydrolasesPhosphatidylinositolsPhosphoinositide 5-PhosphatasesReceptors, Antigen, T-CellAntibodiesPhosphatidylinositolsPhosphoinositide 5-PhosphatasesPhosphoric Monoester HydrolasesReceptors, Antigen, T-Cell

Identifiers

PMID37670137
PMCPMC10480498
OpenAlexW4386448111

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.