Evidence map›Paper›PMID 37672793›Full record

ArticleProteomics. Clinical applications2024

Associations of inflammation-related proteome with demographic and clinical characteristics of people with HIV in South Africa.

Junyu Chen, Qin Hui, Chang Liu, Jaysingh Brijkumar, Johnathan A Edwards, Claudia E Ordóñez, Mathew R Dudgeon, Henry Sunpath, Selvan Pillay, Pravi Moodley and 5 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proteomics. Clinical applications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 77% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 3 countries.

Junyu ChenDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.ORCID 0000-0001-9659-0225
Qin HuiDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.
Chang LiuDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.
Jaysingh BrijkumarNelson R Mandela School of Medicine, University of KwaZulu Natal, Durban, South Africa.
Johnathan A EdwardsDepartment of Biostatistics and Bioinformatics and School of Medicine, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.
Claudia E OrdóñezHubert Department of Global Health, Rollins School of Public Health, Atlanta, Georgia, USA.
Mathew R DudgeonDepartment of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
Henry SunpathNelson R Mandela School of Medicine, University of KwaZulu Natal, Durban, South Africa.
Selvan PillayNelson R Mandela School of Medicine, University of KwaZulu Natal, Durban, South Africa.
Pravi MoodleySchool of Laboratory Medicine and Medical Sciences, National Health Laboratory Service, University of KwaZulu-Natal, Durban, South Africa.
Daniel R KuritzkesBrigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Mohamed Y S MoosaNelson R Mandela School of Medicine, University of KwaZulu Natal, Durban, South Africa.
Tooru NemotoPublic Health Institute, Oakland, California, USA.
Vincent C MarconiHubert Department of Global Health, Rollins School of Public Health, Atlanta, Georgia, USA.
Yan V SunDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.
Emory University · USUniversity of KwaZulu-Natal · ZABrigham and Women's Hospital · USGeorgia Department of Public Health · USNational Health Laboratory Service · ZAProduction Management Institute of Southern Africa · ZAPublic Health Institute · US

Funding

Virology and Molecular Biomarkers CoreP30AI050409 · NIAID · EMORY UNIVERSITY · PI Ann M Chahroudi, Colleen F Kelley · 2002 to 2026
$74.0M
Multi-omic Predictors of Renal Function among HIV-infected Individuals of African AncestryR01DK125187 · NIDDK · EMORY UNIVERSITY · PI MARCONI, VINCENT CHARLES, SUN, YAN · 2020 to 2024
$4.1M
Antiretroviral drug resistance in KwaZulu NatalR01AI098558 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI KURITZKES, DANIEL R., MARCONI, VINCENT CHARLES · 2013 to 2017
$2.3M
NIAID NIH HHS P30 AI050409NIAID NIH HHS R01 AI098558NIDDK NIH HHS R01 DK125187
6 · The paper itself

Abstract

purposeElevated levels of inflammation associated with human immunodeficiency virus (HIV) infection are one of the primary causes for the burden of age-related diseases among people with HIV (PWH). Circulating proteins can be used to investigate pathways to inflammation among PWH. EXPERIMENTAL

designWe profiled 73 inflammation-related protein markers and assessed their associations with chronological age, sex, and CD4

resultsWe identified 1, 1, and 14 inflammatory proteins significantly associated with sex, CD4 CONCLUSIONS AND CLINICAL RELEVANCE: We found that advanced age may lead to the elevation of multiple inflammatory proteins among PWH. We also demonstrated the potential utility of proteomics for evaluating and characterizing the inflammatory status of PWH.

Indexed as

Cardiovascular DiseasesHIV InfectionsAntigens, NeoplasmCell Adhesion MoleculesDemographyHumansInflammationMaleProteomeSouth AfricaAntigens, NeoplasmCDCP1 protein, humanCell Adhesion MoleculesProteomeagingHIVinflammationproteins

Identifiers

PMID37672793
PMCPMC13432066
OpenAlexW4386468652

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.