Evidence map›Paper›PMID 37673973›Full record

ArticleLeukemia2023

CAR virus receptor mediates erythroid differentiation and migration and is downregulated in MDS.

Karin Bauer, Sigrid Machherndl-Spandl, Lukas Kazianka, Irina Sadovnik, Sinan Gültekin, Susanne Suessner, Johannes Proell, Jeroen Lauf, Gregor Hoermann, Gregor Eisenwort and 16 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Leukemia, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors at 8 institutions in 3 countries.

Karin Bauer *Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria.ORCID 0000-0001-9927-042X
Sigrid Machherndl-Spandl *Department of Internal Medicine I, Ordensklinikum, Linz, Austria.
Lukas Kazianka *Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria.
Irina SadovnikDepartment of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria.
Sinan GültekinDepartment of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria.
Susanne Suessner
Johannes ProellMedical Faculty, Johannes Kepler University, Linz, Austria.
Jeroen LaufLabor Europaplatz, Linz, Austria.
Gregor HoermannLudwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, Vienna, Austria.ORCID 0000-0002-7374-4380
Gregor EisenwortDepartment of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria.
Norman HäfnerDepartment of Gynaecology and Obstetrics, Jena University Hospital, Jena, Germany.ORCID 0000-0002-7012-483X
Mathilde Födermayr-MayrleitnerLaboratory for Molecular and Genetic Diagnostics, Ordensklinikum, Linz, Austria.
Ann-Sofie SchmolkeDepartment of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria.
Emiel van der KouweDepartment of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria.
Uwe PlatzbeckerDivision of Hematology, University of Dresden, Dresden, Germany.ORCID 0000-0003-1863-3239
Thomas LionChildren´s Cancer Research Institute Vienna und Department of Pediatrics, Medical University of Vienna, Vienna, Austria.
Ansgar WeltermannDepartment of Internal Medicine I, Ordensklinikum, Linz, Austria.
Otto ZachLaboratory for Molecular and Genetic Diagnostics, Ordensklinikum, Linz, Austria.
Gerald WebersinkeLaboratory for Molecular and Genetic Diagnostics, Ordensklinikum, Linz, Austria.
Ulrich GermingDepartment of Hematology, Oncology and Clinical Immunology, Medical University of Düsseldorf, Düsseldorf, Germany.
Christian GabrielDepartment of Molecular Biology, Transfusion Service of Upper Austria, Linz, Austria.ORCID 0000-0003-2043-9320
Wolfgang R SperrDepartment of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria.
Marie C BénéHematology Laboratory, CHU de Nantes, Nantes, France.
Philipp B StaberDepartment of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria.ORCID 0000-0001-6729-7708
Peter BettelheimLabor Europaplatz, Linz, Austria.
Peter ValentDepartment of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria. peter.valent@meduniwien.ac.at.ORCID 0000-0003-0456-5095
Medical University of Vienna · ATKepler Universitätsklinikum · ATJohannes Kepler University of Linz · ATCentre Hospitalier Universitaire de Nantes · FRHeinrich Heine University Düsseldorf · DEJena University Hospital · DEMunich Leukemia Laboratory (Germany) · DEUniversity Hospital Leipzig · DE

Funding

Austrian Science Fund FWF F 4701Austrian Science Fund FWF F 4704Austrian Science Fund FWF P 30625
6 · The paper itself

Abstract

Myelodysplastic syndromes (MDS) are myeloid neoplasms presenting with dysplasia in the bone marrow (BM) and peripheral cytopenia. In most patients anemia develops. We screened for genes that are expressed abnormally in erythroid progenitor cells (EP) and contribute to the pathogenesis of MDS. We found that the Coxsackie-Adenovirus receptor (CAR = CXADR) is markedly downregulated in CD45

Indexed as

AnemiaMyelodysplastic SyndromesAnimalsBone Marrow CellsCell Adhesion MoleculesCell DifferentiationHumansMiceMice, Inbred C57BLReceptors, VirusCell Adhesion MoleculesReceptors, Virus

Identifiers

PMID37673973
PMCPMC7615770
OpenAlexW4386482321

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.