Evidence map›Paper›PMID 37674078›Full record

ArticleNature2023

Pervasive downstream RNA hairpins dynamically dictate start-codon selection.

Yezi Xiang, Wenze Huang, Lianmei Tan, Tianyuan Chen, Yang He, Patrick S Irving, Kevin M Weeks, Qiangfeng Cliff Zhang, Xinnian Dong

Open access · hybridAbstract read
In one paragraph

Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed
10.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 69 citations in OpenAlex.

  1. Article
  2. Mechanisms and balanced regulation of plant immunity.Nature reviews. Molecular cell biology · 2026
    Review
  3. Article
  4. Article
  5. RNA regulation in plants.Science China. Life sciences · 2026
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. RNA Structure Coordinates Translation Across the Meiotic Program.bioRxiv : the preprint server for biology · 2026
    Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Science advances · 2025
    Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Yezi XiangDepartment of Biology, Duke University, Durham, NC, USA.ORCID 0000-0002-7773-2483
Wenze HuangMOE Key Laboratory of Bioinformatics, Center for Synthetic and Systems Biology, School of Life Sciences, Tsinghua University, Beijing, China.ORCID 0009-0009-6597-7190
Lianmei TanDepartment of Pharmacology and Cancer Biology, Duke Medical Center, Duke University, Durham, NC, USA.ORCID 0000-0002-1445-4375
Tianyuan ChenDepartment of Biology, Duke University, Durham, NC, USA.ORCID 0000-0003-3159-4342
Yang HeDepartment of Biology, Duke University, Durham, NC, USA.ORCID 0009-0002-2622-5796
Patrick S IrvingDepartment of Chemistry, University of North Carolina, Chapel Hill, NC, USA.ORCID 0000-0003-2562-0890
Kevin M WeeksDepartment of Chemistry, University of North Carolina, Chapel Hill, NC, USA.ORCID 0000-0002-6748-9985
Qiangfeng Cliff ZhangMOE Key Laboratory of Bioinformatics, Center for Synthetic and Systems Biology, School of Life Sciences, Tsinghua University, Beijing, China.ORCID 0000-0002-4913-0338
Xinnian DongDepartment of Biology, Duke University, Durham, NC, USA. xdong@duke.edu.ORCID 0000-0002-1120-0951
Howard Hughes Medical Institute · USCenter for Life Sciences · CNUniversity of North Carolina at Chapel Hill · USDuke Medical Center · US

Funding

Discovery and Function of Higher-Order RNA StructureR35GM122532 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Kevin M Weeks · 2017 to 2026
$5.7M
NIGMS NIH HHS R35 GM122532
6 · The paper itself

Abstract

Translational reprogramming allows organisms to adapt to changing conditions. Upstream start codons (uAUGs), which are prevalently present in mRNAs, have crucial roles in regulating translation by providing alternative translation start sites

Indexed as

Codon, InitiatorNucleic Acid ConformationRNA, Double-StrandedRNA, MessengerArabidopsisDEAD-box RNA HelicasesDeep LearningHumansInnate Immunity RecognitionOpen Reading FramesProtein BiosynthesisRibosomesSaccharomyces cerevisiae ProteinsTranscriptomeCodon, InitiatorDDX3X protein, humanDEAD-box RNA HelicasesDED1 protein, S cerevisiaeRNA, Double-StrandedRNA, MessengerSaccharomyces cerevisiae Proteins

Identifiers

PMID37674078
PMCPMC10499604
OpenAlexW4386468736

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.