Evidence map›Paper›PMID 37674148›Full record

Observational studyBMC infectious diseases2023

Immune responses of patients on maintenance hemodialysis after infection by SARS-CoV-2: a prospective observational cohort study.

Dimitra Bacharaki, Minas Karagiannis, Panagiotis Giannakopoulos, Evangelos Papachristou, Dimitrios Divanis, Aggeliki Sardeli, Dimitra Petrou, Petros Nikolopoulos, Adamantia Bratsiakou, Vassiliki Zoi and 5 more

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMC infectious diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Dimitra BacharakiDepartment of Nephrology, University General Hospital Attikon, Athens, Greece. bacharaki@gmail.com.
Minas KaragiannisDepartment of Nephrology, University General Hospital Attikon, Athens, Greece.
Panagiotis GiannakopoulosDepartment of Nephrology, University General Hospital Attikon, Athens, Greece.
Evangelos PapachristouDepartment of Nephrology, Rion University Hospital, University of Patras, Patras, Greece.
Dimitrios Divanis2nd Department of Nephrology, AHEPA Hospital, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Aggeliki SardeliDepartment of Nephrology, University General Hospital Attikon, Athens, Greece.
Dimitra PetrouDepartment of Nephrology, University General Hospital Attikon, Athens, Greece.
Petros NikolopoulosDepartment of Nephrology, University General Hospital Attikon, Athens, Greece.
Adamantia BratsiakouDepartment of Nephrology, Rion University Hospital, University of Patras, Patras, Greece.
Vassiliki ZoiDepartment of Nephrology, University General Hospital Attikon, Athens, Greece.
Nikitas PiliourasDepartment of Nephrology, University General Hospital Attikon, Athens, Greece.
Georgia Damoraki4th Department of Internal Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Vassilios Liakopoulos2nd Department of Nephrology, AHEPA Hospital, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Dimitrios GoumenosDepartment of Nephrology, Rion University Hospital, University of Patras, Patras, Greece.
Evangelos J Giamarellos-Bourboulis4th Department of Internal Medicine, National and Kapodistrian University of Athens, Athens, Greece.
University General Hospital Attikon · GRUniversity of Patras · GRAristotle University of Thessaloniki · GRNational and Kapodistrian University of Athens · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundImmune dysregulation in patients with acute COVID-19 under chronic hemodialysis (CHD) is fully not elucidated. The changes of mononuclear counts and mediators before and after HD and associations with final outcome were studied.

methodIn this prospective study, hospitalized patients with moderate-to-severe COVID-19 under CHD and matched comparators under HD were analyzed for their absolute counts of lymphoid cells and circulating inflammatory mediators. Blood samples were collected before start and at the end of the first HD session; dialysate samples were also collected.

resultFifty-nine patients with acute COVID-19 under CHD and 20 uninfected comparators under CHD were enrolled. Circulating concentrations of tumor necrosis factor-alpha (TNFα), interleukin (IL)-10, interferon-γ and platelet-derived growth factor-A were increased in patients. Concentrations of mediators did not differ before and after HD. Significant decreases of CD4-lymphocytes and CD19-lymphocytes were found in patients. The decrease of the expression of HLA-DR on CD14-monocytes was associated with unfavorable outcome (defined as WHO-CPS 6 or more by day 28); increased counts of CD19-lymphocytes were associated with better outcomes.

conclusionPatients under CHD develop an inflammatory reaction to SARS-CoV-2 characterized by increase of inflammatory mediators, decrease of circulating T-lymphocytes and decrease of the expression of HLA-DR on CD14-monocytes.

Indexed as

COVID-19SARS-CoV-2HumansImmunityInflammation MediatorsProspective StudiesRenal DialysisInflammation MediatorsCOVID-19CytokinesHemodialysisHLA-DRImmune response

Identifiers

PMID37674148
PMCPMC10481459
OpenAlexW4386481898

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.