Evidence map›Paper›PMID 37680049›Full record

ArticleCancer medicine2023

Beta IV spectrin inhibits the metastatic growth of melanoma by suppressing VEGFR2-driven tumor angiogenesis.

Eun-A Kwak, Tasmia Ahmed, Paola Cruz Flores, Hannah R Ortiz, Paul R Langlais, Karthikeyan Mythreye, Nam Y Lee

Open access · goldAbstract read
In one paragraph

Article in Cancer medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Eun-A KwakDepartment of Pharmacology, University of Arizona, Tucson, Arizona, USA.ORCID 0000-0002-3412-3565
Tasmia AhmedDepartment of Chemistry & Biochemistry, University of Arizona, Tucson, Arizona, USA.
Paola Cruz FloresDepartment of Chemistry & Biochemistry, University of Arizona, Tucson, Arizona, USA.
Hannah R OrtizDepartment of Pharmacology, University of Arizona, Tucson, Arizona, USA.
Paul R LanglaisDepartment of Medicine, University of Arizona, Tucson, Arizona, USA.
Karthikeyan MythreyeDepartment of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Nam Y LeeDepartment of Pharmacology, University of Arizona, Tucson, Arizona, USA.ORCID 0000-0002-3730-0774
University of Arizona · USUniversity of Alabama at Birmingham · US

Funding

VITAMIN AP30CA023074 · NCI · UNIVERSITY OF ARIZONA · PI Dan Theodorescu · 1985 to 2026
$110.2M
University of Arizona's Initiative for Maximizing Student Development (IMSD)T32GM139779 · NIGMS · UNIVERSITY OF ARIZONA · PI FRANS E TAX · 2022 to 2026
$2.9M
Tumor-intrinsic and paracrine roles of endoglin in pancreatic cancerR01CA275036 · NCI · UNIVERSITY OF ARIZONA · PI Nam Y Lee · 2023 to 2026
$1.5M
NCI NIH HHS P30 CA023074NCI NIH HHS R01 CA275036NIGMS NIH HHS T32 GM139779
6 · The paper itself

Abstract

backgroundTumor-associated angiogenesis mediates the growth and metastasis of most solid cancers. Targeted therapies of the VEGF pathways can effectively block these processes but often fail to provide lasting benefits due to acquired resistance and complications.

resultsRecently, we discovered β

Indexed as

Melanoma, ExperimentalSpectrinAnimalsEndothelial CellsMiceNeovascularization, PathologicSpectrinSptbn4 protein, mouseangiogenesisendothelial cellstumor vascularizationvascular growth factorβIV-spectrin

Identifiers

PMID37680049
PMCPMC10557856
OpenAlexW4386529146

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.