Evidence map›Paper›PMID 37680339›Full record

ArticleNeurophotonics2023

Enhancing diffuse correlation spectroscopy pulsatile cerebral blood flow signal with near-infrared spectroscopy photoplethysmography.

Kuan Cheng Wu, Alyssa Martin, Marco Renna, Mitchell Robinson, Nisan Ozana, Stefan A Carp, Maria Angela Franceschini

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Neurophotonics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06994494 (Noninvasive Continuous BP Monitoring in Newborns Based on Pulsatile Signal Morphological Features Using NIRS), which is not on this map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06994494 recruitingnot on this mapstarted 2025, after this paper: background citation

Noninvasive Continuous BP Monitoring in Newborns Based on Pulsatile Signal Morphological Features Using NIRS

TypeobservationalSponsorMassachusetts General HospitalRan2025 to 2026Enrolled80ConditionsUnstable Blood Pressure, Hypotension
3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Kuan Cheng WuMassachusetts General Hospital, Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, Massachusetts, United States.ORCID https://orcid.org/0000-0002-7794-8022
Alyssa MartinMassachusetts General Hospital, Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, Massachusetts, United States.
Marco RennaMassachusetts General Hospital, Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, Massachusetts, United States.
Mitchell RobinsonMassachusetts General Hospital, Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, Massachusetts, United States.ORCID https://orcid.org/0000-0001-5810-0459
Nisan OzanaMassachusetts General Hospital, Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, Massachusetts, United States.ORCID https://orcid.org/0000-0001-6025-3243
Stefan A CarpMassachusetts General Hospital, Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, Massachusetts, United States.ORCID https://orcid.org/0000-0003-4617-3233
Maria Angela FranceschiniMassachusetts General Hospital, Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, Massachusetts, United States.ORCID https://orcid.org/0000-0001-6758-423X
Massachusetts General Hospital · USAthinoula A. Martinos Center for Biomedical Imaging · USBoston University · US

Funding

Time-Gated Diffuse Correlation Spectroscopy for functional imaging of the human brainU01EB028660 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI FRANCESCHINI, MARIA ANGELA · 2019 to 2023
$6.4M
Neuroimaging Training ProgramT32EB001680 · NIBIB · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BRUCE R ROSEN · 2003 to 2026
$3.8M
DCS cerebral blood flow monitor for extreme low-birth-weight infantsR01HD091067 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI EL-DIB, MOHAMED, FRANCESCHINI, MARIA ANGELA · 2018 to 2022
$3.3M
Acousto-optic modulated interferometric DCS (iDCS) operating at 1064 nmR21EB028626 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI FRANCESCHINI, MARIA ANGELA · 2019 to 2020
$456k
NIBIB NIH HHS R21 EB028626NIBIB NIH HHS T32 EB001680NIBIB NIH HHS U01 EB028660NICHD NIH HHS R01 HD091067
6 · The paper itself

Abstract

Significance: Combining near-infrared spectroscopy (NIRS) and diffuse correlation spectroscopy (DCS) allows for quantifying cerebral blood volume, flow, and oxygenation changes continuously and non-invasively. As recently shown, the DCS pulsatile cerebral blood flow index ( Aim: Although current DCS technology allows for reliable monitoring of the slow hemodynamic changes, resolving pulsatile blood flow at large source-detector separations, which is needed to ensure cerebral sensitivity, is challenging because of its low signal-to-noise ratio (SNR). Cardiac-gated averaging of several arterial pulse cycles is required to obtain a meaningful waveform. Approach: Taking advantage of the high SNR of NIRS, we demonstrate a method that uses the NIRS photoplethysmography (NIRS-PPG) pulsatile signal to model DCS Results: In 10 healthy subjects, we verified the quality of the NIRS-PPG Conclusions: NIRS-PPG improves DCS

Indexed as

cerebral blood flowcerebrovascular resistancecritical closing pressurediffuse correlation spectroscopynear-infrared spectroscopy

Identifiers

PMID37680339
PMCPMC10482352
OpenAlexW4386469450

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.